Evidence map›Paper›PMID 41224654›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells.

Ewan St John Smith, Michael D Burton, Anne-Marie Heegaard, Cheryl L Stucky

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ewan St John SmithDepartment of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom es336@cam.ac.uk.ORCID 0000-0002-2699-1979
Michael D BurtonNeuroimmunology and Behavior Laboratory, Department of Neuroscience, School of Behavioral and Brain Sciences, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, Texas 75080.ORCID 0000-0002-0628-824X
Anne-Marie HeegaardDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0003-2754-0800
Cheryl L StuckyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.ORCID 0000-0003-4966-6594

Funding

Nociceptive Mechanisms Underlying Sickle Cell PainR01NS070711 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI Bonnie N Dittel, Cheryl Louise Stucky · 2009 to 2026
$8.7M
FUNCTIONAL ANALYSIS OF DISTINCT NOCICEPTOR POPULATIONSR01NS040538 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI STUCKY, CHERYL LOUISE · 2000 to 2019
$6.2M
Pain Mechanisms in Fabry DiseaseR37NS108278 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI STUCKY, CHERYL LOUISE · 2019 to 2025
$5.6M
Mechanisms involved in postoperative recovery: a focus on pain, delirium, and neuroinflammationR35GM147094 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Michael D Burton · 2022 to 2026
$1.9M
The role of cell-specific TLR4 in Diabetic Peripheral NeuropathyR21DK130015 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI BURTON, MICHAEL D · 2022 to 2024
$577k
NIDDK NIH HHS R21 DK130015NIGMS NIH HHS R35 GM147094NINDS NIH HHS R01 NS040538NINDS NIH HHS R01 NS070711NINDS NIH HHS R37 NS108278
6 · The paper itself

Abstract

Pain is a symptom common to a wide variety of conditions and one that severely impacts an individual's everyday life, as well as having broader socioeconomic repercussions. In recent years, there has been spectacularly rapid progress in the understanding of the molecular basis of sensory neuron function and pain in preclinical models. However, the number of analgesics interacting with novel targets that have received regulatory approval in recent years has been limited. Examples include monoclonal antibody and small molecule therapies disrupting calcitonin gene-related peptide signaling for treating migraine and, most recently, suzetrigine, a small molecular inhibitor of the voltage-gated sodium channel Na

Indexed as

NeuronsPainSensory Receptor CellsAnimalsHumans

Identifiers

PMID41224654
PMCPMC12614054

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.