Evidence map›Paper›PMID 41224656›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.

Antoine D Madar, Aaron D Milstein, Thomas J O'Dell, Anant Jain, Claudia Clopath, Mark E J Sheffield

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Increased CA3 burst activity inbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antoine D MadarDepartment of Neurobiology, Neuroscience Institute, University of Chicago, Chicago, Illinois 60637 madar@uchicago.edu.ORCID 0000-0002-5408-7047
Aaron D MilsteinDepartment of Neuroscience and Cell Biology and Center for Advanced Biotechnology and Medicine, Rutgers Heath, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854.ORCID 0000-0002-7186-5779
Thomas J O'DellDepartment of Physiology, David Geffen School of Medicine, and Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095.ORCID 0000-0002-9231-8694
Anant JainCentre for High Impact Neuroscience and Translational Applications (CHINTA), TCG CREST, Kolkata, West Bengal 700091, India.ORCID 0000-0002-0262-6264
Claudia ClopathDepartment of Bioengineering, Imperial College London, London SW72AZ, United Kingdom.ORCID 0000-0003-4507-8648
Mark E J SheffieldDepartment of Neurobiology, Neuroscience Institute, University of Chicago, Chicago, Illinois 60637.ORCID 0000-0003-0969-7820

Funding

From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampusRF1NS127123 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2022 to 2022
$1.9M
Investigation of a thalamic-hippocampal pathway in contextual fear suppression and extinctionR01MH136274 · NIMH · UNIVERSITY OF CHICAGO · PI Mark E J Sheffield · 2024 to 2026
$1.9M
CRCNS: Coordinating learning by top-down gating of plasticity in dendritesR01MH135576 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MILSTEIN, AARON D · 2023 to 2024
$813k
The role of dentate gyrus input-output computations in episodic memoryF32MH126643 · NIMH · UNIVERSITY OF CHICAGO · PI MADAR, ANTOINE DAVID · 2021 to 2024
$230k
NIMH NIH HHS F32 MH126643NIMH NIH HHS R01 MH135576NIMH NIH HHS R01 MH136274NINDS NIH HHS RF1 NS127123
6 · The paper itself

Abstract

Hebbian synaptic plasticity is currently the main framework to relate neuronal activity, network structure, and learning and memory. However, recent experimental and computational modeling studies have revealed a new form of synaptic plasticity termed behavioral timescale synaptic plasticity (BTSP). It is triggered by dendritic plateau potentials associated with somatic burst firing, causes large changes in synaptic strength in a single shot, and operates on the timescale of seconds. Here we review the recent advances in our understanding of the circuit, cellular, and molecular mechanisms of BTSP, its prevalence in the brain, its role in shaping neuronal representations, and the emerging ideas regarding its contribution to different forms of learning.

Indexed as

LearningMemoryNeuronal PlasticitySynapsesAction PotentialsAnimalsBrainHumansModels, NeurologicalNeurons

Identifiers

PMID41224656
PMCPMC12614050

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.