ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Astrocytes as Therapeutic Targets in Neurodegenerative Disorders.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Astrocytes viewed through the lens of their proteomes and subproteomes.Nature reviews. Neuroscience · 2026Review
- Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Astrocyte Functional Heterogeneity in Multiple Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes play crucial roles in central nervous system homeostasis, regulating neuronal and synaptic activity, modulating immune responses, and preserving the integrity of the blood-brain barrier. Recent genetic, transcriptomic, and proteomic studies have highlighted astrocytes as key players in the pathogenesis of neurodegenerative disorders. Yet, important questions remain unanswered: How are astrocyte functions changed across different neurodegenerative disorders? Does astrocyte reactivity contribute to neurodegenerative cascades? Can astrocyte-specific processes be targeted for therapy? This review summarizes recent findings on the potential contribution of astrocytes to disease onset and progression, with a focus on their therapeutic potential. It also explores the application of advanced omics technologies to unravel astrocyte complexity, along with the use of emerging murine models and human-induced pluripotent stem cells based systems to explore astrocyte involvement in disease mechanisms.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.