Evidence map›Paper›PMID 41224673›Full record

ArticleZoological research2025

VEGFR-3 deficiency in astrocytes exacerbates Japanese encephalitis virus-induced neuroinflammation in mouse brains.

Xi-Lin Wang, Qi Zhao, Hong-Yang Liu, Yong-Sheng Dai, Ming-Shun Han, Xiao-Jing Li, Feng Li, Jing Ye, Sheng-Bo Cao, Lin-Lin Qi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xi-Lin WangSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Qi ZhaoSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Hong-Yang LiuSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Yong-Sheng DaiSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Ming-Shun HanState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Xiao-Jing LiInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
Feng LiState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Jing YeState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Sheng-Bo CaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China. E-mail: sbcao@mail.hzau.edu.cn.
Lin-Lin QiSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China. E-mail: qilinlin@shu.edu.cn.
Bin WeiSchool of Medicine, School of Life Sciences, Shanghai University, Shanghai 200444, China. E-mail: weibinwhy@shu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Japanese encephalitis virus (JEV), a highly neurotropic flavivirus, preferentially targets neurons, where it replicates efficiently and induces extensive neuroinflammation and neural injury within the central nervous system (CNS), resulting in severe neurological deficits and high mortality. Vascular endothelial growth factor receptor 3 (VEGFR-3), a receptor tyrosine kinase encoded by

Indexed as

AstrocytesBrainEncephalitis, JapaneseEncephalitis Virus, JapaneseNeuroinflammatory DiseasesVascular Endothelial Growth Factor Receptor-3AnimalsGene Expression RegulationMiceMice, Inbred C57BLVascular Endothelial Growth Factor Receptor-3AstrocytesJEVNeuroinflammatory responseVEGFR-3

Identifiers

PMID41224673
PMCPMC12940548

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.