Evidence map›Paper›PMID 41224748›Full record

ArticleNPJ science of food2025

Screening and analysis of malt pentapeptide DPP-IV inhibitory activity.

Yi He, Yan Zhang, Pengying Zhang, Jiaying Li, Wannan Li, Weiwei Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi He *Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China.
Yan Zhang *Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China.
Pengying ZhangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China.
Jiaying LiKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China.
Wannan LiKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China. liwannan@jlu.edu.cn.
Weiwei HanKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond Fischer Cell Signaling Laboratory, College of Life Sciences, Jilin University, Changchun, China. weiweihan@jlu.edu.cn.

Funding

the Science and Technology Development Program Project in Jilin Province of China 20230508072RC
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) poses a significant global health burden, with dipeptidyl peptidase-IV (DPP-IV) inhibitors being critical therapeutic targets for its management. Malt, a natural medicinal food, shows promise for T2DM treatment, yet its active compounds need further exploration. This study integrates molecular docking (Libdock, Autodock Vina), deep learning models (ConPlex, KPGT), molecular dynamics (MD) simulations, and network pharmacology to identify and validate DPP-IV inhibitors from malt. The pentapeptide YPQPQ, derived from malt hordein, exhibited potent DPP-IV inhibition (IC

Identifiers

PMID41224748
PMCPMC12612193

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.