Evidence map›Paper›PMID 41224760›Full record

ArticleNature communications2025

YTHDF2 regulates self non-coding RNA metabolism to control inflammation and tumorigenesis.

Seungwon Yang, Yan-Hong Cui, Haixia Li, Jiangbo Wei, Gayoung Park, Ming Sun, Michelle Verghese, Emma Wilkinson, Teresa Nam, Linnea Louise Lungstrom and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The mJournal of virology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Seungwon Yang *Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA. syang80research@gmail.com.ORCID http://orcid.org/0000-0002-8970-7373
Yan-Hong Cui *Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4169-6521
Haixia Li *Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Jiangbo Wei *Departments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2691-6490
Gayoung ParkDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Ming SunDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Michelle VergheseDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Emma WilkinsonDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Teresa NamThe College, University of Chicago, Chicago, IL, USA.
Linnea Louise LungstromThe College, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2989-674X
Xiaolong CuiDepartments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Tae Young RyuDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA.
Jing ChenDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Marc BissonnetteDepartment of Medicine, Section of Gastroenterology, Hepatology & Nutrition, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8420-4294
Chuan HeDepartments of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4319-7424
Yu-Ying HeDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA. yyhe@uchicago.edu.ORCID http://orcid.org/0000-0002-2665-7962

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0M
YTHDF2 and UVB damage response in skin cancerR01ES024373 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2015 to 2023
$4.3M
Epitranscriptomic mechanism of environmental stress response and tumorigenesisR35ES031693 · NIEHS · UNIVERSITY OF CHICAGO · PI Yu-Ying He · 2023 to 2026
$4.2M
NCATS NIH HHS UL1 TR000430NCI NIH HHS P30 CA014599NICHD NIH HHS T32 HD007009NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES024373NIEHS NIH HHS R35 ES031693U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA014599U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES027792U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES031693, ES024373
6 · The paper itself

Abstract

The role of m

Indexed as

CarcinogenesisInflammationRNA-Binding ProteinsRNA, UntranslatedAnimalsAutophagyEndosomesHEK293 CellsHumansKeratinocytesMethylationMiceMice, Inbred C57BLMice, KnockoutSkinToll-Like Receptor 3RNA-Binding ProteinsRNA, UntranslatedTLR3 protein, mouseToll-Like Receptor 3YTHDF2 protein, humanYTHDF2 protein, mouse

Identifiers

PMID41224760
PMCPMC12612255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.