ArticleNature communications2025
Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- From Correlation to Cure: rTMS on Chronic Visceral Pain in IBS-D.Neuroscience bulletin · 2026Article
- Multisite Chronic Pain Reveals Neuro-Immune-Metabolic Dysregulation across Rheumatoid Arthritis and Depression.Research (Washington, D.C.) · 2026Article
- From images to physics-based computational models to digital twins: a framework for personalized cancer therapies.Frontiers in radiology · 2026Article
- Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.Nature communications · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
Chronic pain represents a major clinical burden, with its intensity being a key measure of its severity. However, the genetic and neural underpinnings of chronic pain intensity remain unraveled. Here, we identified six genetic loci (including a novel discovery) significantly associated with chronic pain intensity using a genome-wide association study in the UK Biobank (n = 134,627). We then systematically investigate its relationship with 3924 brain imaging-derived phenotypes. Phenotypic correlation analyses revealed 29 imaging-derived phenotypes predictive of future chronic pain intensity. Genetic correlation and polygenic risk score analyses showed 13 of these imaging-derived phenotypes share a genetic basis with chronic pain intensity. Mediation analyses indicated that 12 imaging-derived phenotypes mediate genetic effects on chronic pain intensity. Mendelian randomization further supported a causal influence of three imaging-derived phenotypes, including brain structure and functional network connectivity, on chronic pain intensity. Our findings elucidate the genetic architecture and neurobiological pathways of chronic pain intensity, highlighting the brain's central role in chronic pain pathophysiology.
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Registered trials
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