Evidence map›Paper›PMID 41224793›Full record

ArticleNPJ breast cancer2025

Immunogenomic diversity of triple-negative breast cancers in obese and non-obese black and white women.

Fokhrul Hossain, Denise Danos, Jovanny Zabaleta, Xiao-Cheng Wu, Luis Del Valle, Chindo Hicks, Jiande Wu, Jerneja Tomsic, Susan Neuhausen, Yuan Chun Ding and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fokhrul Hossain *Department of Genetics, Louisiana State University Health Center, New Orleans, LA, USA.
Denise Danos *School of Public Health, Louisiana State University Health Center, New Orleans, LA, USA.
Jovanny Zabaleta *Department of Interdisciplinary Oncology, Louisiana State University Health Center, New Orleans, LA, USA.
Xiao-Cheng WuSchool of Public Health, Louisiana State University Health Center, New Orleans, LA, USA.
Luis Del ValleDepartment of Interdisciplinary Oncology, Louisiana State University Health Center, New Orleans, LA, USA.
Chindo HicksDepartment of Genetics, Louisiana State University Health Center, New Orleans, LA, USA.
Jiande WuDepartment of Genetics, Louisiana State University Health Center, New Orleans, LA, USA.
Jerneja TomsicDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Susan NeuhausenDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Yuan Chun DingDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Kavitha MukundDepartment of Bioengineering, University of California, San Diego, USA.
Zahra MesrizadehDepartment of Bioengineering, University of California, San Diego, USA.
Shankar SubramaniamDepartment of Bioengineering, University of California, San Diego, USA.
Augusto OchoaDepartment of Interdisciplinary Oncology, Louisiana State University Health Center, New Orleans, LA, USA.
Victoria SeewaldtDepartment of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Lucio MieleDepartment of Genetics, Louisiana State University Health Center, New Orleans, LA, USA. lmiele@lsuhsc.edu.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Pilot ProjectP20CA202922 · NCI · LSU HEALTH SCIENCES CENTER · PI GREGORY, PAULA ELIZABETH, MIELE, LUCIO · 2017 to 2020
$987k
NCI NIH HHS P20 CA202922NCI NIH HHS P20CA202922NIGMS NIH HHS 2U54GM104940NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Racial disparities in incidence and outcomes of triple-negative breast cancer (TNBC) have been attributed to ancestry, socioeconomic factors and/or obesity. We studied 253 TNBCs from 128 Black and 125 White women. Arms were balanced for age, AJCC stage, histological grade and molecular subtypes, and differed significantly in BMI distribution, obesity, and Area Deprivation Index. We examined survival rates, whole-transcriptome RNASeq and genetic ancestry. In our sample, Black race or obesity were not intrinsically predictive of poor outcomes. TNBC molecular portraits varied with stage and biological aggressiveness, irrespective of race. We identified a novel group of TNBCs with a distinctive luminal-like and stem-cell-like transcriptional profile that were equally distributed among Blacks and Whites. Genetic ancestry was highly admixed. Immune deconvolution showed a higher abundance of several immune cell populations in tumors from Blacks, which may have precision therapeutic significance, warranting further investigation of potential drivers of tumor immunity.

Identifiers

PMID41224793
PMCPMC12612227

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.