ArticleScientific reports2025
Alterations in renal Na,K-ATPase activity and protein expression in rat models of pressure and volume overload.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo explore an unexamined mechanism of cardiorenal pathophysiology by assessing renal Na, K-ATPase kinetics in rat models of pressure overload, volume overload, and their combination.
methodsTwo rat models with differing renin-angiotensin-aldosterone system activity were used: control Hannover Sprague Dawley (HAN) rats and transgenic TGR(mREN2)27 rats, the later modeling pressure overload. Each model included sham and aortocaval fistula (ACF)-operated groups to induce volume overload. The kinetic parameters of Na,K-ATPase were determined: maximal velocity of enzyme reaction (V
resultsHistological studies, along with assessment of selected markers of renal injury and remodeling, confirmed kidney tissue alterations in both TGR(mREN2)27 rats and animals subjected to ACF-surgery. Regarding Na,K-ATPase, V
conclusionWith regard to functional properties of the Na, K-ATPase, an increased number of substrate molecules converted to products per active site per unit time (indicated by V
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