Evidence map›Paper›PMID 41224950›Full record

Trial reportScientific reports2025

The consumption of onion extract tablet modulates expression of human plasma microRNAs: a randomized placebo-controlled clinical trial.

Mao Yamamoto, Yoshinori Fujimura, Ryotaro Chiba, Modena Shimizu, Motofumi Kumazoe, Akane Haseda, Jun Nishihira, Mari Maeda-Yamamoto, Hirofumi Tachibana

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mao Yamamoto *Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Yoshinori Fujimura *Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Ryotaro Chiba *Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Modena ShimizuDivision of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Motofumi KumazoeDivision of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Akane HasedaDepartment of Medical Management and Informatics, Hokkaido Information University, Ebetsu, 069-8585, Japan.
Jun NishihiraDepartment of Medical Management and Informatics, Hokkaido Information University, Ebetsu, 069-8585, Japan.
Mari Maeda-YamamotoInstitute of Food Research, National Agriculture and Food Research Organization, Tsukuba, 305-8643, Japan.
Hirofumi TachibanaDivision of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. tatibana@agr.kyushu-u.ac.jp.

Funding

Bio-oriented Technology Research Advancement Institution SIP2BJapan Society for the Promotion of Science 23H02163Japan Society for the Promotion of Science JP20H05683
6 · The paper itself

Abstract

MicroRNAs (miRNAs), which are non-coding RNAs of approximately 20 nucleotides in length, have attracted attention for their involvement in various biological processes and the regulation of diseases. However, the effects of foods and supplements on miRNA expression in vivo remain unclear. Onion extract tablets (OET) alleviate male menopausal symptoms and stress; however, their effects on miRNA expression in vivo are unknown. Herein, we investigated the effects of OET on miRNA expression in vivo. A randomized, double-blind, placebo-controlled study was conducted on 19 healthy Japanese participants (men and women) aged 30-65 years. Participants consumed either a placebo tablet (PT) or OET which included 30 mg of sulfur-containing amino acids daily for 2 weeks. MiRNAs prepared from plasma samples before and after intake were comprehensively analyzed using next-generation sequencing. A comparison of the variation before and after intake showed that the expression levels of three miRNAs, miR-106b-5p, miR-339-3p, and miR-181b-5p, were significantly increased in the OET group than in the PT group. Receiver operating characteristic analysis of these miRNAs also showed that miR-106b-5p had the highest discriminatory power. To our knowledge, this study is the first to show that consumption of onion extract can modulate miRNA expression in humans.

Indexed as

Gene Expression RegulationMicroRNAsOnionsPlant ExtractsAdultAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedTabletsMicroRNAsPlant ExtractsTabletsClinical traialFood intake biomarkerMicroRNAOnionSulfur-containing amino acids

Identifiers

PMID41224950
PMCPMC12612263

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.