ArticleClinical rheumatology2026
Association of blood pressure with knee pain progression over 4 years in middle-aged and elderly individuals with or at risks for osteoarthritis: data from the Osteoarthritis Initiative.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo investigate the association between blood pressure and knee pain progression in individuals with or at risk for osteoarthritis (OA).
methodThis retrospective, multicenter, cohort study utilized a total of 2906 subjects (61.7% female, aged 45-79 years) from the Osteoarthritis Initiative. Blood pressure parameters included diastolic blood pressure, systolic blood pressure, pulse pressure (PP), and hypertension stage. Knee pain severity was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Knee Injury and Osteoarthritis Outcome Score, and the Numeric Rating Scale. Binary logistic regression was conducted to evaluate associations between blood pressure parameters and knee pain progression. Sensitivity analyses were performed for significant findings using exposure quartiles, multiple imputation, and linear regression of continuous pain score changes. Potential effect modification was tested using interaction analyses.
resultsElevated PP was significantly associated with weight-bearing WOMAC pain progression (Odd ratio = 1.09, 95% Confidence Interval: 1.02-1.17, p = 0.014). The association remained significant in sensitivity analyses using PP quartiles (trend p = 0.011) and multiple imputation (OR = 1.08, 95% CI: 1.01-1.16, p = 0.021). No significant interactions were detected between PP and sex, body mass index, diabetes, Kellgren-Lawrence grade, pain management treatment, and antihypertensive medication use.
conclusionsThis study revealed a significant relationship between PP and the weight-bearing knee pain progression in individuals with or at risk for primary OA, suggesting a vascular factor in OA pathogenesis. Limitations include the observational design and potential residual confounding. Key Points • Elevated pulse pressure is associated with weight-bearing knee pain progression. • A threshold-like association was observed, with a significant effect at higher pulse pressure levels.
Indexed as
Identifiers
41225241What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.