Evidence map›Paper›PMID 41225264›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Surgical management of congenital C2 over C3 spondyloptosis with severe cervical kyphosis: two case reports.

Shaodong Mo, Yuanquan Chen, Zhen Che, Jing Xu, Rald Groven, Frank Hildebrand, Honglei Yi, Hu Chen, Fuzhi Ai

Abstract readCase Reports
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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shaodong Mo *Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSU), 510120, Guangzhou, China.
Yuanquan Chen *Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSU), 510120, Guangzhou, China.
Zhen CheClinic for Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Jing XuDepartment of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSU), 510120, Guangzhou, China.
Rald GrovenClinic for Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Frank HildebrandExperimental Orthopaedics and Trauma Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Honglei YiDepartment of Orthopedics, People's Liberation Army General Hospital of Southern Theatre Command, 510010, Guangzhou, China.
Hu ChenDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, 200020, Shanghai, China. chenflew@126.com.
Fuzhi AiDepartment of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSU), 510120, Guangzhou, China. spine2000@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to report the surgical management and outcomes of two rare cases of congenital C2 over C3 spondyloptosis with severe cervical kyphosis (CK) caused by bilateral axial appendage abnormalities, providing insights into individualized surgical strategies for this complex condition.

methodsTwo patients with distinct clinical presentations were included. Case 1: A 4-year-old girl with progressive CK and limb weakness underwent anterior cervical discectomy, C3 corpectomy, and fusion via a submandibular approach using autologous iliac bone grafting and customized plate fixation. Case 2: A 16-year-old female with recurrent C2 over C3 spondyloptosis after failed prior surgery underwent anterior revision (transoral approach) with C2/4 fusion and posterior occipitocervical fusion. Preoperative/postoperative clinical, radiographic, and neurological outcomes were analyzed.

resultsBoth patients achieved significant kyphosis correction (Case 1: 88° to 11°; Case 2: 63° to 8°), adequate spinal cord decompression, and neurological recovery (Case 1: ASIA grade B to E; Case 2: ASIA grade C to E). Postoperative imaging confirmed stable fixation and bony fusion. No complications occurred during a follow-up of 5 years.

conclusionCongenital C2 over C3 spondyloptosis with CK requires tailored surgical approaches based on age, anatomical anomalies, and prior interventions. Anterior or combined anterior-posterior strategies effectively restore stability, correct deformity, and relieve neurological deficits. Long-term monitoring is essential, particularly in pediatric patients, to address growth-related challenges.

Indexed as

Cervical VertebraeKyphosisSpinal FusionSpondylolisthesisAdolescentChild, PreschoolDiskectomyFemaleHumansTreatment OutcomeC2 over C3 spondyloptosisCervical kyphosisCongenital cervical deformitySpinal fusion

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.