SynthesisBMC gastroenterology2025
The effect of intravenous anesthesia on postoperative cognitive function in patients undergoing painless gastroscopy: a meta-analysis.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the development of comfortable medical care, the application of intravenous anesthesia in painless gastroscopy is becoming increasingly widespread. However, anesthetic drugs may have adverse effects on postoperative cognitive function, and the risk of postoperative cognitive dysfunction (POCD) is particularly worthy of attention in the elderly population. Our aim is to evaluate the effect of intravenous anesthesia on postoperative cognitive function (POCF) in patients undergoing painless gastroscopy, with a focus on identifying potential risks of POCD and guiding clinical anesthesia practices.
methodsAnalyzing randomized controlled trials (RCTs) published in English that assessed the impact of intravenous anesthesia on POCF in patients over 60 years old undergoing elective gastrointestinal endoscopy. The literature search spanned databases including PubMed、Embase、Web of Science、Scopus、Cochrane, and Clinical Key. Study inclusion and exclusion criteria were rigorously defined, and the Cochrane bias risk assessment tool was utilized to evaluate study quality. Meta-analyses were performed using RevMan 5.3, with heterogeneity assessed via I-square statistics.
resultsFrom a total of 432 articles identified, 7 studies involving 219 patients met the inclusion criteria. The meta-analysis revealed no significant difference in the incidence rates of POCD on Day 1 and Day 3 postoperatively between patients undergoing intravenous versus inhalation anesthesia. However, on Day 7, the incidence of POCD was significantly lower in the intravenous anesthesia group, with a combined Odds Ratio (OR) of 0.96 (95% Confidence Interval (CI): 0.73-1.26, I^2 = 34%, n = 7, P < 0.00001). Furthermore, plasma levels of S-100β protein, a marker for neural injury, were significantly lower in the intravenous anesthesia group, with a Mean Difference (MD) of 0.34 (95% CI: 0.23-0.48, I^2 = 0%, n = 5, P < 0.00001).
conclusionIntravenous anesthesia for painless gastroscopy appears to be associated with a lower incidence of POCD on Day 7 postoperatively, suggesting a potentially reduced risk of early postoperative cognitive decline compared to inhalation anesthesia. The findings indicate that intravenous anesthesia may be preferable in minimizing the risk of POCD, particularly in older adults undergoing painless gastroscopy. However, further high-quality, large-scale RCTs are warranted to validate these results and explore the effects across different patient demographics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.