ArticleBMC endocrine disorders2025
Differentiating diabetes type in children and adolescents with ketosis or ketoacidosis at onset: a retrospective analysis of clinical and biochemical markers.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDistinguishing diabetes diagnosis is fundamental to ensuring proper management of individuals with diabetes, but has been challenging, especially in newly diagnosed diabetes onset with ketosis or ketoacidosis in pediatrics.
methodsA retrospective analysis was conducted on medical records from 2017/1/1 to 2020/4/30 in pediatrics with new-onset diabetes accompanied with ketosis or ketoacidosis. Data was collected at diabetes onset and two years after discharge. Persons with diabetes were classified as type 1 or 2 diabetes (T1DM; T2DM) based on the person’s medication and final diagnosis. The best diagnostic cut-off point was determined using receiver operating characteristic curves (ROCs) between T1DM and T2DM.
resultsAmong 153 children and adolescent with diabetes, 78 (51.0%) were diagnosed as T1DM and 75 (49.0%) were diagnosed as T2DM after two years of follow-up. There were significant differences in sex, age, family history, BMI, systolic and diastolic blood pressure, lipids, uric acid (UA), C-peptide, combined fatty liver ratio and any islet auto-antibody-positive ratio at the time of onset (P < 0.05). Key discriminators identified by ROC analysis included fatty liver, SBP, BMI, and C-peptide levels (fasting, 1-h, and 2-h), with AUCs of 0.79, 0.83, 0.92, 0.94, 0.96, and 0.95 and optimal cut-offs value of 110.5 mmHg, 20.95 kg/m², 0.47 nmol/L (fasting), 0.98 nmol/L (1-h), and 2.03 nmol/L (2-h), respectively.
conclusionsOverall, the most sensitive and specific clinical and biochemical criteria for the diagnostic classification of newly diagnosed diabetes onset with ketosis or ketoacidosis in pediatrics should consider C-peptide, BMI, SBP and fatty liver at the time of onset, which have effective diagnostic values. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.