ArticleNutrition journal2025
Association of body roundness index with risk of all-cause, cardiovascular disease-cause, and cancer-cause mortality: the role of biological age acceleration.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveThis study aims to explore the association of BRI with all-cause, cardiovascular disease (CVD)-cause, and cancer-cause mortality risk, and the role of biological age acceleration (BAA) in mediating these associations.
methodsWe included 305,406 participants in the UK biobank. BRI was calculated based on waist circumference (WC) and height. BAA was divided into klemera-doubal method biological age acceleration (KDM-BA) and PhenoAge acceleration. The associations of BRI, BAA with outcomes were assessed by Cox proportional hazard models. The role of BAA in this association was analyzed by mediating effect.
resultsCompared with the individuals with the lowest BRI quartile, the individuals with the highest BRI quartile had a higher hazard of death, and the HR and 95% CI of all-cause death, CVD death and cancer death were (HR: 1.43 (95% CI: 1.33, 1.53)), (HR: 1.47 (95% CI: 1.25, 1.72)), (HR: 1.38 (95% CI: 1.26, 1.52)), respectively. The mediation proportion of BAA in associations of BRI with death outcomes were 10.75–42.98% (all p < 0.001).
conclusionBRI is associated with an increased hazard of all-cause death, CVD death, and cancer death, BAA partially mediated these associations. We observed that higher levels of BRI were associated with an increased hazard of death, with biological age acceleration potentially mediating this association. This suggests that maintaining a healthy lifestyle and reducing the inflammatory/immune response and lipid metabolism abnormalities associated with obesity are critical to reducing the burden of chronic disease. The future intervention targets will be maintaining WC at appropriate levels that might contribute to self-health management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.