Evidence map›Paper›PMID 41226225›Full record

ArticleMolecules (Basel, Switzerland)2025

The Role of the NO/cGMP Pathway and SKCa and IKCa Channels in the Vasodilatory Effect of Apigenin 7-Glucoside.

Maria Luiza Fidelis da Silva, Erdi Can Aytar, Arquimedes Gasparotto Junior

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Luiza Fidelis da SilvaLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados 79804-970, MS, Brazil.
Erdi Can AytarFaculty of Agriculture, Department of Horticulture, Usak University, 64200 Uşak, Türkiye.ORCID 0000-0001-6045-0183
Arquimedes Gasparotto JuniorLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados 79804-970, MS, Brazil.ORCID 0000-0003-3433-5098

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 407685/2018-9 and 150258/2023-2Coordenadoria de Aperfeiçoamento de Pessoal de Nível Superior s/nFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul 71/700.135/2018 and 83/013.186/2023
6 · The paper itself

Abstract

This study aimed to elucidate the vasorelaxant mechanism of action for apigenin 7-glucoside (A7G) by integrating computational and ex vivo pharmacological approaches. Molecular docking simulations were conducted to predict the binding affinities and interactions of A7G with key vascular proteins, specifically human endothelial nitric oxide synthase (eNOS-PDB ID: 1M9M), and human intermediate (IKCa-PDB ID: 9ED1) and small-conductance (SKCa-PDB ID: 6CNN) Ca

Indexed as

ApigeninCyclic GMPGlucosidesIntermediate-Conductance Calcium-Activated Potassium ChannelsNitric OxidePotassium Channels, Calcium-ActivatedSmall-Conductance Calcium-Activated Potassium ChannelsVasodilationVasodilator AgentsAnimalsHumansMaleMolecular Docking SimulationNitric Oxide Synthase Type IIIRatsRats, Inbred SHRApigeninCyclic GMPGlucosidesIntermediate-Conductance Calcium-Activated Potassium ChannelsNitric OxideNitric Oxide Synthase Type IIIPotassium Channels, Calcium-ActivatedSmall-Conductance Calcium-Activated Potassium ChannelsVasodilator AgentsFlavoneK+ channelsmesenteric vascular bedvasodilation

Identifiers

PMID41226225
PMCPMC12610067

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.