Evidence mapPaperPMID 41226321Full record

ReviewInternational journal of molecular sciences2025

Decoding the Lipid Droplet Proteome: New Frontiers in Cardiovascular Disease Research.

Alice Mallia, Giulia G Papaianni, Lisa Brocca, Cristina Banfi, Erica Gianazza

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Omics Technologies in Molecular Biology.International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alice MalliaCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics and Network Analysis, Via Parea 4, 20138 Milan, Italy.ORCID 0000-0002-7088-9074
Giulia G PapaianniCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics and Network Analysis, Via Parea 4, 20138 Milan, Italy.ORCID 0009-0005-3657-4043
Lisa BroccaCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics and Network Analysis, Via Parea 4, 20138 Milan, Italy.ORCID 0009-0005-0824-3167
Cristina BanfiCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics and Network Analysis, Via Parea 4, 20138 Milan, Italy.ORCID 0000-0003-3346-9879
Erica GianazzaCentro Cardiologico Monzino IRCCS, Unit of Functional Proteomics, Metabolomics and Network Analysis, Via Parea 4, 20138 Milan, Italy.ORCID 0000-0003-2370-947X

Funding

Italian network of excellence for advanced diagnosis funded by the Ministry of Health PNC-E3-2022-23683266
6 · The paper itself

Abstract

Lipid droplets (LDs) are cellular dynamic organelles involved in lipid storage and maintaining lipid balance. They contain many proteins on their surface that significantly affect their functions and behaviors. Thus, it becomes crucial to characterize the LD proteome using appropriate "omics" technologies that may contribute to an accurate understanding of the LD roles in human diseases. Indeed, LDs and their associated proteins are involved in several pathologies related to dysfunctional lipid metabolism, such as hyperlipidemia, obesity, metabolic syndrome, and cardiovascular diseases (CVDs). This review aims to provide an overview of "omics" studies focused on characterizing the LD proteome in the cardiovascular field, offering additional insight into the involvement of LDs in the development and progression of heart complications, as well as defining potential targets useful for diagnostic, preventive, and therapeutic approaches for patients.

Indexed as

Cardiovascular DiseasesLipid DropletsProteomeAnimalsHumansLipid MetabolismProteomicsProteomecardiovascular diseaseslipid dropletsomics approachesproteomics

Identifiers

PMID41226321
PMCPMC12610607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.