Evidence map›Paper›PMID 41226327›Full record

ArticleInternational journal of molecular sciences2025

Robust and Reproducible Monoclonal Antibody Production Using a Transgenic Silkworm System.

Seiki Yageta, Yudai Nagata, Mamoru Shimizu, Natsumi Yasaka, Takuma Iwasa, Takushi Nakajima, Takeo Kuwata, Shuzo Matsushita, Masahiro Tomita

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seiki YagetaImmuno-Biological Laboratories, Co., Ltd., 1091-1 Naka Aza-Higashida, Fujioka 375-0005, Gunma, Japan.
Yudai NagataImmuno-Biological Laboratories, Co., Ltd., 1091-1 Naka Aza-Higashida, Fujioka 375-0005, Gunma, Japan.
Mamoru ShimizuImmuno-Biological Laboratories, Co., Ltd., 1091-1 Naka Aza-Higashida, Fujioka 375-0005, Gunma, Japan.
Natsumi YasakaCURED Inc., 8-16 Anseimachi Chuo-ku, Kumamoto 860-0801, Japan.
Takuma IwasaCURED Inc., 8-16 Anseimachi Chuo-ku, Kumamoto 860-0801, Japan.
Takushi NakajimaCURED Inc., 8-16 Anseimachi Chuo-ku, Kumamoto 860-0801, Japan.
Takeo KuwataThe Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Shuzo MatsushitaThe Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.ORCID 0000-0002-9649-8821
Masahiro TomitaImmuno-Biological Laboratories, Co., Ltd., 1091-1 Naka Aza-Higashida, Fujioka 375-0005, Gunma, Japan.

Funding

Research Program on HIV/AIDS from the Japan Agency for Medical Research and Development JP22fk0410054h0001Research Program on HIV/AIDS from the Japan Agency for Medical Research and Development JP23fk0410054h0002Research Program on HIV/AIDS from the Japan Agency for Medical Research and Development JP24fk0410054h0003the Public/Private R&D Investment Strategic Expansion PrograM PRISM
6 · The paper itself

Abstract

Transgenic silkworms are promising host organisms for the production of therapeutic recombinant proteins due to their superior protein synthesis ability and human-like posttranslational modifications. In this study, we generated transgenic silkworms that secrete a recombinant human monoclonal antibody (mAb) against gp120 of human immunodeficiency virus (HIV) into their cocoons. Variations in the rearing temperature and humidity conditions had little effect on mAb properties, such as

Indexed as

Antibodies, MonoclonalBombyxAnimalsAnimals, Genetically ModifiedGlycosylationHumansLarvaRecombinant ProteinsAntibodies, MonoclonalRecombinant Proteinsimmunoglobulin Grecombinant protein productiontransgenic silkworm

Identifiers

PMID41226327
PMCPMC12607763

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.