ReviewInternational journal of molecular sciences2025
The Therapeutic Potential of Extracellular Vesicles in Psoriasis Treatment: Mechanisms, Applications, and Prospects.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Extracellular vesicles: Revolutionizing targeted therapy for ischemic stroke.Acta pharmaceutica Sinica. B · 2026Review
- Exosomes in Psoriasis: From Pathogenic Mechanisms to Therapeutic Innovations.Clinical, cosmetic and investigational dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Psoriasis is a chronic inflammatory skin disease driven by dysregulated immune responses and aberrant keratinocyte (KC) proliferation, with a profound impact on patient quality of life. Emerging evidence highlights extracellular vesicles (EVs) as promising therapeutic candidates in regenerative medicine, offering new avenues for psoriasis management. This review provides a critical overview of psoriasis pathophysiology and evaluates the mechanistic basis of EV-based therapies, emphasizing their immunomodulatory capacity to restore immune homeostasis. We synthesize findings from preclinical studies, demonstrating the therapeutic potential of EVs derived from diverse cellular sources, including their ability to attenuate inflammation, regulate immune responses, enhance wound repair, and modulate KC function. Finally, we explore future directions aimed at optimizing EV therapeutic efficacy and translating these findings into clinical practice. Collectively, this review underscores EVs as a novel, targeted, and cell-free therapeutic strategy with the potential to transform psoriasis treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.