Evidence map›Paper›PMID 41226361›Full record

ReviewInternational journal of molecular sciences2025

CDK4/6 Inhibitors in Breast Cancer-Who Should Receive Them?

Anran Chen, Ze-Yi Zheng, Meenakshi Anurag, Ahmed Elkhanany, Natalie C Chen, Eric C Chang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anran ChenResearch Oncology, Bayer, Cambridge, MA 02142, USA.
Ze-Yi ZhengLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Meenakshi AnuragLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Ahmed ElkhananyLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Natalie C ChenLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Eric C ChangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

Funding

Translational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5M
DOD HT94252410103DOD W81XWH-21-1-0106DOD W81XWH-21-1-0634NIH HHS 1P50CA186784-05NIH HHS P50CA186784
6 · The paper itself

Abstract

More than 70% of breast cancers are estrogen receptor-positive (ER

Indexed as

Breast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Protein Kinase InhibitorsFemaleHumansCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Protein Kinase Inhibitorsbreast cancerCDK4/6estrogen receptorneurofibromatosisRAFRAS

Identifiers

PMID41226361
PMCPMC12610100

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.