Evidence map›Paper›PMID 41226366›Full record

ArticleInternational journal of molecular sciences2025

Anticancer Activity of Triterpene Glycosides Cucumarioside A

Elena A Zelepuga, Ekaterina A Chingizova, Ekaterina S Menchinskaya, Evgeny A Pislyagin, Sergey A Avilov, Vladimir I Kalinin, Dmitry L Aminin, Alexandra S Silchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. AMarine drugs · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena A ZelepugaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-0208-2121
Ekaterina A ChingizovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0003-0093-5757
Ekaterina S MenchinskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.
Evgeny A PislyaginG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-3558-0821
Sergey A AvilovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.
Vladimir I KalininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-7360-5401
Dmitry L AmininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-1073-4994
Alexandra S SilchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-Letya Vladivostoka 159, 690022 Vladivostok, Russia.ORCID 0000-0002-9367-1158

Funding

Russian Science Foundation 23-13-00078
6 · The paper itself

Abstract

Breast cancer is the most prevalent cancer in women worldwide and presents a major therapeutic challenge, particularly triple-negative breast cancer (TNBC), a subtype characterized by an aggressive clinical course but heightened sensitivity to chemotherapy. Natural products, such as triterpene glycosides derived from sea cucumbers, have emerged as promising candidates with high anticancer potential against TNBC. This study investigated the pathways of anticancer action of cucumarioside A

Indexed as

Antineoplastic AgentsGlycosidesReceptor, Adenosine A2BSaponinsTriple Negative Breast NeoplasmsTriterpenesAnimalsCalciumCell Line, TumorCell ProliferationCyclic AMPFemaleHumansMAP Kinase Signaling SystemMolecular Docking SimulationAntineoplastic AgentsCalciumCyclic AMPGlycosidesReceptor, Adenosine A2BSaponinsTriterpenesA2BARadenosine receptorsantagonistanticancerMAPKMDA-MB-231molecular docking and dynamicstriple-negative breast cancer (TNBC)triterpene glycosides

Identifiers

PMID41226366
PMCPMC12607671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.