Evidence map›Paper›PMID 41226438›Full record

ArticleInternational journal of molecular sciences2025

Sumac Polyphenols as Pan-Herpesvirus Inhibitors.

Shavkat I Salikhov, Yuliya I Oshchepkova, Jamolitdin F Ziyavitdinov, Jamshid M Ashurov, Nodir S Berdiev, Mikhail S Kolundin, Akhmed O Gaidarov, Ali S Turgiev, Kirill I Yurlov, Victor F Larichev and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current issues in molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shavkat I SalikhovSadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan.
Yuliya I OshchepkovaSadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan.ORCID 0000-0002-4619-458X
Jamolitdin F ZiyavitdinovSadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan.ORCID 0000-0001-8337-1218
Jamshid M AshurovSadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan.
Nodir S BerdievSadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Tashkent 100125, Uzbekistan.ORCID 0000-0002-3914-2714
Mikhail S KolundinGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Akhmed O GaidarovGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Ali S TurgievGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0002-0500-6407
Kirill I YurlovGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0002-4694-2445
Victor F LarichevGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0001-8262-5650
Irina T FedyakinaGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Valeria L AndronovaGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Natalia E FedorovaGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0001-8466-7993
Alla A KushchGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0002-3396-5533
Alexander V IvanovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-5659-9679
Eduard V KaramovGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0003-1162-118X

Funding

Ministry of Higher Education, Science and Innovation of Uzbekistan ALM-202304076-07Russian ministry of science and higher education № 075-15-2024-678
6 · The paper itself

Abstract

Pandemic preparedness is a complex of threat-agnostic countermeasures developed in advance which would be efficient against a future outbreak regardless of its causative agent, and broad-spectrum antivirals constitute a critical component of this complex. Plant polyphenols are known to suppress viruses of unrelated families by acting on multiple viral and cellular structures. We therefore searched for broad-spectrum antivirals among polyphenols that have been confirmed as safe to humans. The ellagitannin geraniin and galloylglucose constituents of the drug Rutan (1,2,3,4,6-penta-O-galloyl-β-D-glucose [R5], 3-bis-O-galloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose [R6], 2,4-bis-O-galloyl-1,3,6-tri-O-galloyl-β-D-glucose [R7], 2,3,4-bis-O-galloyl-1,6-di-O-galloyl-β-D-glucose [R8]) were isolated from

Indexed as

Antiviral AgentsHerpesviridaePolyphenolsAnimalsChlorocebus aethiopsGeraniumGlucosidesHumansHydrolyzable TanninsVero CellsAntiviral AgentsGeraniinGlucosidesHydrolyzable TanninsPolyphenolscytomegalovirusEpstein–Barr virusgeraniumherpes simplex virus type 1herpes simplex virus type 2influenza A viruspolyphenolsSARS-CoV-2sumac

Identifiers

PMID41226438
PMCPMC12607321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.