Evidence map›Paper›PMID 41226485›Full record

ArticleInternational journal of molecular sciences2025

TFAM Loss Induces Oxidative Stress and Divergent Phenotypes in Glioblastoma Metabolic Subtypes.

Stella G Cavalcante, Roseli da S Soares, Miyuki Uno, Maria J F Alves, Ricardo C Cintra, Paula R Sola, Christiane Y Ozaki, Antonio M Lerário, Sueli M Oba-Shinjo, Suely K N Marie

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stella G CavalcanteCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0002-2449-3773
Roseli da S SoaresCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0002-1828-5046
Miyuki UnoCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0003-2589-6432
Maria J F AlvesCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.
Ricardo C CintraDepartment of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.ORCID 0000-0002-5374-5319
Paula R SolaCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0001-6452-1436
Christiane Y OzakiCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.
Antonio M LerárioDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8336-6432
Sueli M Oba-ShinjoCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0002-1650-5973
Suely K N MarieCellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Room 4110-Pacaembu, 4th Floor, Av. Dr. Arnaldo, 455, São Paulo 01246-903, SP, Brazil.ORCID 0000-0003-4419-7928

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2004/12133-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/02988-9
6 · The paper itself

Abstract

Mitochondrial transcription factor A (TFAM) is essential for mitochondrial DNA (mtDNA) maintenance and function, but its role in glioblastoma (GBM) remains largely unexplored. Analysis of patient astrocytomas and TCGA datasets has revealed progressive

Indexed as

Brain NeoplasmsDNA-Binding ProteinsGlioblastomaMitochondrial ProteinsOxidative StressTranscription FactorsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMitochondriaPhenotypeReactive Oxygen SpeciesDNA-Binding ProteinsMitochondrial ProteinsReactive Oxygen SpeciesTFAM protein, humanTranscription FactorsGBMmitochondrial dysfunctionredox balanceTFAM

Identifiers

PMID41226485
PMCPMC12610520

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.