Evidence map›Paper›PMID 41226529›Full record

ReviewInternational journal of molecular sciences2025

The Ca

Luis Molina Calistro, Yennyfer Arancibia, Javiera Alarcón, Rodrigo Flavio Torres

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luis Molina CalistroFacultad de Ciencias, Universidad San Sebastián, Lago Panguipulli 1390, Puerto Montt 5501842, Chile.
Yennyfer ArancibiaFacultad de Ciencias, Universidad San Sebastián, Lago Panguipulli 1390, Puerto Montt 5501842, Chile.
Javiera AlarcónFacultad de Medicina, Universidad San Sebastián, Lago Panguipulli 1390, Puerto Montt 5501842, Chile.
Rodrigo Flavio TorresFacultad de Ciencias, Universidad San Sebastián, Lago Panguipulli 1390, Puerto Montt 5501842, Chile.ORCID 0000-0002-4328-2920

Funding

Agencia Nacional de Investigación y Desarrollo 11230898Agencia Nacional de Investigación y Desarrollo 11240855Agencia Nacional de Investigación y Desarrollo 3200655ANID-MILENIO NCN2023_032
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused primarily by mutations in the gene encoding the methyl-CpG-binding protein 2 (Mecp2). Mecp2 binds to methylated cytosines, playing a crucial role in chromatin organization and transcriptional regulation. At the neurobiological level, RTT is characterized by dendritic spine dysgenesis and altered excitation-inhibition balance, drawing attention to the mechanisms that scale from mutations in a nuclear protein to altered neuronal connectivity. Although Mecp2 dysfunction disrupts multiple neuronal processes, emerging evidence highlights altered calcium (Ca

Indexed as

CalciumCalcium SignalingNeuronsRett SyndromeAnimalsBrain-Derived Neurotrophic FactorHumansMethyl-CpG-Binding Protein 2MicroRNAsMutationRyanodine Receptor Calcium Release ChannelBrain-Derived Neurotrophic FactorCalciumMECP2 protein, humanMethyl-CpG-Binding Protein 2MicroRNAsRyanodine Receptor Calcium Release Channelcalciumcalcium signalingMecp2neuronal function and dysfunctionRett syndromeryanodine receptors

Identifiers

PMID41226529
PMCPMC12609203

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.