Evidence mapPaperPMID 41226556Full record

ArticleInternational journal of molecular sciences2025

Hormonal and Sex-Specific Regulation of Key Players in Fibro-Calcific Aortic Valve Disease.

Katherina Neussl, Sarah Werner, Holger Thiele, Florian Schlotter, Michael A Borger, Petra Büttner, Julia Böttner

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherina NeusslDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.ORCID 0009-0006-1547-2651
Sarah WernerDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.
Holger ThieleDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.ORCID 0000-0002-0169-998X
Florian SchlotterDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.
Michael A BorgerDepartment of Cardiac Surgery, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.ORCID 0000-0003-1046-1364
Petra BüttnerDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.ORCID 0000-0003-0799-4725
Julia BöttnerDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male sex and aging are risk factors for fibro-calcific aortic valve disease (FCAVD), indicating an understudied influence of sex hormones. Valvular interstitial cells (VICs) from female and male donors were isolated and exposed to pro-calcifying medium (PM), and the expression of matrix gla protein (MGP), fibronectin (FN1) and bone morphogenic protein 2 (BMP2) was analyzed. The effect of sex hormones on hydroxyapatite (HA) deposition by VICs was also analyzed. Exposure to PM increased MGP gene expression in male (

Indexed as

Aortic ValveAortic Valve StenosisCalcinosisGonadal Steroid HormonesAdultAgedBone Morphogenetic Protein 2Calcium-Binding ProteinsDihydrotestosteroneDurapatiteExtracellular Matrix ProteinsFemaleFibronectinsGene Expression RegulationHumansMaleBMP2 protein, humanBone Morphogenetic Protein 2Calcium-Binding ProteinsDihydrotestosteroneDurapatiteExtracellular Matrix ProteinsFibronectinsFN1 protein, humanGonadal Steroid HormonesMatrix Gla ProteinBMP2FCAVDfibronectinMGPsex-specific

Identifiers

PMID41226556
PMCPMC12607358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.