Evidence map›Paper›PMID 41226559›Full record

ArticleInternational journal of molecular sciences2025

AMPK Limits MNNG-Induced Parthanatos by Inhibiting BH3-Only Protein Bim.

Shuhei Hamano, Tomoe Maruyama, Midori Suzuki, Maki Mitsuya, Takumi Yokosawa, Yusuke Hirata, Atsushi Matsuzawa, Takuya Noguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuhei HamanoLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Tomoe MaruyamaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Midori SuzukiLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Maki MitsuyaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Takumi YokosawaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Yusuke HirataLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0002-1428-2075
Atsushi MatsuzawaLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0001-8303-3905
Takuya NoguchiLaboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0001-6187-6645

Funding

Japan Society for the Promotion of Science JP24K02237Japan Society for the Promotion of Science JP25K22513
6 · The paper itself

Abstract

Parthanatos represents an alternative form of regulated cell death (RCD) mediated by poly (ADP-ribose) polymerase-1 (PARP-1). However, the underlying mechanisms and physiological significance of parthanatos are poorly understood. In this study, we investigated molecular mechanisms of parthanatos in human fibrosarcoma HT1080 cells using biochemical and cellular experiments, and found that parthanatos induced by the alkylating agent

Indexed as

AMP-Activated Protein KinasesBcl-2-Like Protein 11MethylnitronitrosoguanidineAdenosine TriphosphateApoptosisbcl-2-Associated X ProteinCell Line, TumorHumansPoly (ADP-Ribose) Polymerase-1Signal TransductionAdenosine TriphosphateAMP-Activated Protein Kinasesbcl-2-Associated X ProteinBCL2L11 protein, humanBcl-2-Like Protein 11MethylnitronitrosoguanidinePARP1 protein, humanPoly (ADP-Ribose) Polymerase-1AMPKBimparthanatos

Identifiers

PMID41226559
PMCPMC12609621

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.