Evidence map›Paper›PMID 41226635›Full record

ArticleInternational journal of molecular sciences2025

Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.

Anna Egorova, Svetlana Freund, Iuliia Krylova, Anastasia Kislova, Anton Kiselev

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna EgorovaLaboratory of Molecular Genetics and Gene Therapy, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint-Petersburg, Russia.
Svetlana FreundLaboratory of Molecular Genetics and Gene Therapy, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint-Petersburg, Russia.
Iuliia KrylovaDepartment of Pathology, Pavlov First Saint-Petersburg State Medical University, L'va Tolstogo Street 6-8, 197022 Saint-Petersburg, Russia.ORCID 0000-0002-8698-7904
Anastasia KislovaLaboratory of Molecular Genetics and Gene Therapy, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint-Petersburg, Russia.ORCID 0009-0007-0450-2365
Anton KiselevLaboratory of Molecular Genetics and Gene Therapy, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint-Petersburg, Russia.ORCID 0000-0002-2487-2423

Funding

Russian Science Foundation 24-15-00498
6 · The paper itself

Abstract

Endometriosis is a common gynecological condition that affects fertility in many women of reproductive age worldwide. This multifaceted disease exhibits a pathogenesis characterized by hormonal and immune system dysregulations, alongside increased angiogenic activity within the peritoneum. The aberrant proliferation of endometrial tissue outside the uterus is associated with vascularization in ectopic endometriotic lesions. Consequently, RNA interference (RNAi)-based angiogenic therapies targeting the

Indexed as

EndometriosisNanoparticlesPeptidesReceptors, CXCR4RNA InterferenceRNA, Small InterferingAnimalsDisease Models, AnimalEndometriumFemaleHumansNeovascularization, PathologicRatsRats, Sprague-DawleyRNAi TherapeuticsVascular Endothelial Growth Factor APeptidesReceptors, CXCR4RNA, Small InterferingVascular Endothelial Growth Factor Aanti-angiogenic therapychemokine-derived peptideCXCR4endometriosisgene therapypeptide-based carrierssiRNA deliveryVEGFA

Identifiers

PMID41226635
PMCPMC12607363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.