Evidence map›Paper›PMID 41226654›Full record

ReviewInternational journal of molecular sciences2025

From Development, Disease, and Decline: A Review of What Defines an Osteoclast Progenitor.

Mitchell J Shimak, Grant Kim, Ismael Y Karkache, Elizabeth K Vu, Emily Chavez, Joseph C Manser, Emily Patterson, Archisha Basak, Keng Cha Vu, Samuel Mitchell and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mitchell J ShimakDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Grant KimDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Ismael Y KarkacheDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0000-9228-647X
Elizabeth K VuDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Emily ChavezDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph C ManserDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Emily PattersonDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Archisha BasakDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Keng Cha VuDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Samuel MitchellDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Jinsha KorothDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Elizabeth W BradleyDepartment of Orthopedic Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8814-5524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our understanding of the different developmental origins of osteoclast progenitors and their respective roles during homeostatic bone remodeling at different skeletal sites as well as their roles within bone regeneration and degenerative conditions is evolving. In this narrative review article, we summarize what is known about the developmental origins, anatomical sources, and markers of osteoclast progenitors. We touch on how osteoclast progenitors vary during different disease contexts, including periodontitis, rheumatoid arthritis, and osteoarthritis. In addition, we also characterize osteoclast progenitors that contribute to bone healing and define changes observed with advancing age. In this regard, we offer a critical review of gaps within our understanding and opportunities for future development within the field. Because of their diverse nature under different contexts, identifying and characterizing osteoclast progenitors may help to advance condition-specific therapies.

Indexed as

OsteoclastsStem CellsAnimalsArthritis, RheumatoidBone RemodelingCell DifferentiationHumansOsteoarthritisarthritisbone healingbone remodelingCSF1CSF1RfractureM-CSFosteomacosteomorphosteoporosisperiodontitisRANKRANKLsurface marker

Identifiers

PMID41226654
PMCPMC12607851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.