ArticleInternational journal of molecular sciences2025
Inhibition of Fatty Acid-Binding Protein 4 Limits High-Fat-Diet-Associated Prostate Tumorigenesis and Progression in TRAMP Mice.
Mingguo Huang, Shintaro Narita, Hiromi Sato, Yuya Sekine, Mizuki Kobayashi, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura and 4 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Mingguo HuangDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.ORCID 0000-0003-1001-3879 Shintaro NaritaDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.ORCID 0000-0003-2988-1860 Hiromi SatoDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Yuya SekineDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Mizuki KobayashiDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Soki KashimaDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Ryohei YamamotoDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Atsushi KoizumiDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Taketoshi NaraDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Kazuyuki NumakuraDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.ORCID 0000-0002-5899-1738 Mitsuru SaitoDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Hiroshi NanjoDepartment of Clinical Pathology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.ORCID 0000-0002-0885-7151 Tomonori HabuchiDepartment of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Funding
Japan Society for the Promotion of Science 24K12479
6 · The paper itselfAbstract
Fatty acid-binding protein 4 (FABP4) is an important adipokine associated with inflammatory responses and metabolic regulation. Although a high-fat diet (HF) and/or HF-mediated obesity have been clearly linked to the progression of prostate cancer, with FABP4 potentially playing a critical role in this relationship, the mechanisms by which FABP4 facilitates this interaction remain unclear. After generating FABP4 knockout (FABP4
Indexed as
AdenocarcinomaCarcinogenesisDiet, High-FatFatty Acid-Binding ProteinsProstatic NeoplasmsAnimalsBiphenyl CompoundsCytokinesDisease ProgressionMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPyrazoles2-(2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy)acetic acidBiphenyl CompoundsCytokinesFabp4 protein, mouseFatty Acid-Binding ProteinsPyrazolesFABP4high-fat dietprostate cancerTRAMP mice
Identifiers
PMID41226657
PMCPMC12607695
What Socratic holds
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