Evidence map›Paper›PMID 41226665›Full record

ArticleInternational journal of molecular sciences2025

NDR2 Kinase Regulates Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity.

Beatriz Fazendeiro, Ivo Machado, Anabela Rolo, Paulo Rodrigues Santos, António Francisco Ambrósio, Paulo F Santos, Hélène Léger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beatriz FazendeiroCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0009-0003-2804-6342
Ivo MachadoCenter for Innovative Biomedicine and Biotechnology (CiBB), University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0002-9666-4594
Anabela RoloCenter for Innovative Biomedicine and Biotechnology (CiBB), University of Coimbra, 3004-504 Coimbra, Portugal.
Paulo Rodrigues SantosCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7519-1620
António Francisco AmbrósioCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-0477-1641
Paulo F SantosCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-2225-455X
Hélène LégerCoimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-1116-8637

Funding

Fundação para a Ciência e a Tecnologia 2022.06170.PTDCFundação para a Ciência e a Tecnologia Projeto n.º 15895 - N(DR)2_EyeUniversidade de Coimbra PEst UIDB/04539/2020, UIDP/04539/2020, UIDB/04539/2025, UIDP/04539/2025
6 · The paper itself

Abstract

Diabetic retinopathy (DR), a major complication of diabetes, is driven by chronic inflammation in which retinal microglial cells play a central role. The Hippo pathway kinases NDR1/2 regulate macrophage function, but their role in microglia and DR remain unknown. This study investigates the function of the NDR2 kinase in microglial cells under high-glucose (HG) conditions. Using CRISPR-Cas9, we partially knocked out the

Indexed as

GlucoseInflammationMicrogliaProtein Serine-Threonine KinasesAdaptor Proteins, Signal TransducingAnimalsCell LineCell MovementCytokinesDiabetic RetinopathyMicePhagocytosisAdaptor Proteins, Signal TransducingCytokinesGlucoseNdr2 protein, mouseProtein Serine-Threonine Kinasesdiabetic retinopathyhigh-glucoseinflammationmetabolismmicrogliaNdr2/Stk38l geneNuclear Dbf2-Related (NDR) kinasesretina

Identifiers

PMID41226665
PMCPMC12609617

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.