Evidence map›Paper›PMID 41226727›Full record

ArticleInternational journal of molecular sciences2025

Instant Cascara Beverage as a Neuroimmune Modulator of the Brain-Gut Axis: Sex-Dependent Effects in Healthy Rats.

Paula Gallego-Barceló, Yolanda López-Tofiño, Laura López-Gómez, Gema Vera, Ana Bagues, Jesús Esteban-Hernández, María Dolores Del Castillo, José Antonio Uranga, Raquel Abalo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paula Gallego-BarcelóDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0002-5729-6696
Yolanda López-TofiñoDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0002-7488-2451
Laura López-GómezDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0001-7352-5703
Gema VeraDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.
Ana BaguesDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.
Jesús Esteban-HernándezDepartment of Medical Specialties and Public Health, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.
María Dolores Del CastilloHigh Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0001-6309-5383
José Antonio UrangaDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0003-4656-8569
Raquel AbaloDepartment of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.ORCID 0000-0002-6726-8795

Funding

Consejo Superior de Investigaciones Científicas 202470E207Ministerio de Ciencia, Innovación y Universidades PID2019-111510RBI00Universidad Rey Juan Carlos Bridge project 2024, A671
6 · The paper itself

Abstract

Instant Cascara (IC), a beverage obtained from dried coffee cherry pulp, represents a sustainable hydration option rich in bioactive phytochemicals, such as caffeine, chlorogenic acids, and melanoidins, which may provide effects beyond basic nutrition. This study evaluated the impact of three weeks of IC consumption on somatic and visceral sensitivity, and on neural and immune markers in the colon of male and female healthy Wistar rats. Behavioral tests showed that IC increased locomotor activity and somatic sensitivity in females (

Indexed as

BeveragesBrainBrain-Gut AxisAnimalsCalcitonin Gene-Related PeptideColonFemaleMaleRatsRats, WistarSex CharacteristicsSex FactorsVisceral PainCalcitonin Gene-Related Peptidebrain–gut axiscoffee by-productenteric nervous systemimmunityphytochemicalsvisceral pain

Identifiers

PMID41226727
PMCPMC12609599

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.