Evidence mapPaperPMID 41226749Full record

SynthesisInternational journal of molecular sciences2025

Non-Coding RNAs (microRNAs, lncRNAs, circRNAs) in Adenomyosis: A Systematic Review of Mechanistic and Translational Evidence.

Rafał Watrowski, Stoyan Kostov, Mario Palumbo, Andrea Rosati, Radmila Sparić, Ibrahim Alkatout, Ingolf Juhasz-Böss, Salvatore Giovanni Vitale, Liliana Mereu

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rafał WatrowskiDepartment of Gynecology, Helios Hospital Müllheim, Teaching Hospital of the University of Freiburg, Heliosweg 1, 79379 Müllheim, Germany.ORCID 0000-0002-6828-1887
Stoyan KostovResearch Institute, Medical University Pleven, 5800 Pleven, Bulgaria.ORCID 0000-0002-5279-3095
Mario PalumboDepartment of Public Health, School of Medicine, University of Naples Federico II, 80138 Naples, Italy.
Andrea RosatiDepartment of Woman's and Child Health and Public Health Sciences, Gynecologic Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Radmila SparićFaculty of Medicine, University of Belgrade, Dr Subotića 8, 11000 Belgrade, Serbia.ORCID 0000-0003-0515-1951
Ibrahim AlkatoutDepartment of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3 (House C), 24105 Kiel, Germany.ORCID 0000-0002-7194-6034
Ingolf Juhasz-BössDepartment of Obstetrics and Gynecology, Medical Center-University Hospital Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-2178-6490
Salvatore Giovanni VitaleObstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, 95124 Catania, Italy.ORCID 0000-0001-6871-6097
Liliana MereuObstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, 95124 Catania, Italy.ORCID 0000-0002-0610-5132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenomyosis (AM) is a hormonally responsive uterine disorder defined by ectopic endometrial tissue within the myometrium, causing pain, abnormal bleeding, and subfertility. Non-coding RNAs (ncRNAs)-including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)-are post-transcriptional regulators implicated also in uterine remodeling. We systematically reviewed original studies evaluating ncRNAs in AM using human samples, in vitro and animal models, or bioinformatic approaches. Data sources included PubMed and Google Scholar (inception up to 10 August 2025). Forty-one studies were included and synthesized across mechanistic, diagnostic, and translational domains. miRNAs (

Indexed as

AdenomyosisMicroRNAsRNA, CircularRNA, Long NoncodingAnimalsFemaleGene Expression RegulationHumansTranslational Research, BiomedicalMicroRNAsRNA, CircularRNA, Long Noncodingadenomyosisbiomarkerscircular RNA (circRNA)diagnosticendometrial–myometrial interfaceepigenetic regulationextracellular vesicles (EV)long non-coding RNA (lncRNA)microRNA (miRNA)non-coding RNA (ncRNA)translational

Identifiers

PMID41226749
PMCPMC12611009

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.