Evidence map›Paper›PMID 41226778›Full record

ArticleInternational journal of molecular sciences2025

Dysregulated DNA Methylation in

Arpita Dave, Anela Tosevska, Marco Morselli, Emily Tom, Matteo Pellegrini, Dorota Skowronska-Krawczyk, Roxana A Radu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arpita DaveUCLA Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0009-0008-1873-0454
Anela TosevskaDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Marco MorselliDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
Emily TomRobert M. Brunson Center for Translational Vision Research, Department of Physiology and Biophysics, Department of Ophthalmology and Visual Sciences, School of Medicine, University of California, Irvine, CA 92697, USA.
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-9355-9564
Dorota Skowronska-KrawczykRobert M. Brunson Center for Translational Vision Research, Department of Physiology and Biophysics, Department of Ophthalmology and Visual Sciences, School of Medicine, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-5758-4225
Roxana A RaduUCLA Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-5064-6403

Funding

NIH HHS 1R01EY000331-10NIH HHS 1R01EY025002-05Research to Prevent Blindness, Inc. na
6 · The paper itself

Abstract

Stargardt disease (STGD1), the most common inherited juvenile macular degeneration, is caused by biallelic mutations in the

Indexed as

ATP-Binding Cassette TransportersDNA MethylationMacular DegenerationRetinal Pigment EpitheliumStargardt DiseaseAnimalsDisease Models, AnimalEpigenesis, GeneticHumansMethyl-CpG-Binding Protein 2MiceMice, KnockoutAbca4 protein, mouseATP-Binding Cassette TransportersMethyl-CpG-Binding Protein 2DNA methylationmethyl-CpG-binding protein 2recessive Stargardt diseasereduced representation bisulfite sequencingretinal pigment epithelium

Identifiers

PMID41226778
PMCPMC12608875

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.