Evidence map›Paper›PMID 41226787›Full record

ReviewInternational journal of molecular sciences2025

Organ-on-a-Chip: A Roadmap for Translational Research in Human and Veterinary Medicine.

Surina Surina, Aleksandra Chmielewska, Barbara Pratscher, Patricia Freund, Alexandro Rodríguez-Rojas, Iwan Anton Burgener

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Surina SurinaClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.
Aleksandra ChmielewskaClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.
Barbara PratscherClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0001-5291-1365
Patricia FreundClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0009-0007-6398-6953
Alexandro Rodríguez-RojasClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.
Iwan Anton BurgenerClinical Department for Small Animals and Horses, Division of Small Animal Internal Medicine, Univesity of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0002-8516-0040

Funding

FWF Austrian Science Fund 37311-B
6 · The paper itself

Abstract

In this review we offer a guide to organ-on-chip (OoC) technologies, covering the full experimental pipeline, from organoid derivation and culture, through microfluidic device fabrication and design strategies, to perfusion systems and data acquisition with AI-assisted analysis. At each stage, we highlight both the advantages and limitations, providing a balanced perspective that aids experimental planning and decision-making. By integrating insights from stem cell biology, bioengineering, and computational analytics, this review presents a compilation of the state of the art of OoC research. It emphasizes practical considerations for experimental design, reproducibility, and functional readouts while also exploring applications in human and veterinary medicine. Furthermore, key technical challenges, standardization issues, and regulatory considerations are discussed, offering readers a clear roadmap for advancing both foundational studies and translational applications of OoC systems.

Indexed as

Lab-On-A-Chip DevicesTranslational Research, BiomedicalVeterinary MedicineAnimalsHumansMicrophysiological SystemsOrganoidsmicrofluidicsorganoidsorgan-on-chiptranslational medicineveterinary models

Identifiers

PMID41226787
PMCPMC12610883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.