Evidence map›Paper›PMID 41226793›Full record

ArticleInternational journal of molecular sciences2025

ABC Transporters, APOE, CYP46A1, and LRP1 Gene Polymorphisms as Markers of Dementia Development in Patients with Hyperlipidemia.

Marta Machowska, Jerzy Leszek, Maja Rączy-Krzemianowska, Beata Tomasiewicz, Magdalena Hurkacz, Małgorzata Rąpała, Janusz Piechota, Krystyna Głowacka, Anna Wiela-Hojeńska

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marta MachowskaDepartment of Clinical Pharmacology, Wrocław Medical University, 50-556 Wrocław, Poland.
Jerzy LeszekDepartment of Psychiatry, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Maja Rączy-KrzemianowskaClinical Department of Internal Medicine, 4th Military Clinical Hospital with Outpatient Clinic, SP ZOZ, 50-981 Wrocław, Poland.
Beata TomasiewiczClinical Department of Internal Medicine, 4th Military Clinical Hospital with Outpatient Clinic, SP ZOZ, 50-981 Wrocław, Poland.
Magdalena HurkaczDepartment of Clinical Pharmacology, Wrocław Medical University, 50-556 Wrocław, Poland.
Małgorzata RąpałaDepartment of Pediatric Surgery, T. Marciniak Lower Silesian Specialist Hospital, 54-049 Wrocław, Poland.ORCID 0000-0002-2789-5911
Janusz PiechotaAmplicon Ltd., 54-413 Wrocław, Poland.
Krystyna GłowackaDepartment of Clinical Pharmacology, Wrocław Medical University, 50-556 Wrocław, Poland.
Anna Wiela-HojeńskaDepartment of Clinical Pharmacology, Wrocław Medical University, 50-556 Wrocław, Poland.ORCID 0000-0003-3813-2300

Funding

Regional Operational Programme of the Lower Silesian Voivodeship 2014-2020, co-financed by the European Union, European Regional Development Fund RPDS.01.02.01-02-0002/20
6 · The paper itself

Abstract

In an aging society, solving problems associated with the diagnosis and treatment of dementia-related diseases represents a serious challenge. The aim of the study was to evaluate the possibility of applying molecular biology methods to test polymorphisms recognized in the global literature as potentially useful in assessing the risk of developing dementia in a group of patients with hyperlipidemia. A sample of 203 patients: 109 diagnosed with both dementia and hyperlipidemia, 94 with hyperlipidemia, and 101 individuals as an allele frequency control group-were genotyped. Additional data about cognitive decline and neuropsychological assessment were collected. Among all the studied polymorphisms, the frequency of the

Indexed as

Apolipoproteins EATP Binding Cassette Transporter 1ATP-Binding Cassette TransportersDementiaHyperlipidemiasLow Density Lipoprotein Receptor-Related Protein-1Polymorphism, Single NucleotideAgedAged, 80 and overAllelesAlzheimer DiseaseBiomarkersCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseABCA1 protein, humanApoE protein, humanApolipoproteins EATP Binding Cassette Transporter 1ATP-Binding Cassette TransportersBiomarkersLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanABCA1ABCB1APOECYP46A1dementiahyperlipidemiaLRPmarkerspolymorphism

Identifiers

PMID41226793
PMCPMC12608497

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.