Evidence map›Paper›PMID 41226800›Full record

ArticleInternational journal of molecular sciences2025

Targeted Sequencing Identifies SNPs Associated with Antimalarial Drug Resistance and the CSP Vaccine Antigen in

Mary T Efeti, Sandra N Fankem, Mariama T Diallo, Methodius S Lahngong, Nelson L Acha, Robert A Shey, Kristiaan Demeyer, Jacob Souopgui, Stephen M Ghogomu, Rose Njemini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Complexity of Infection andmedRxiv : the preprint server for health sciences · 2026
    Article
  2. Haplotype diversity ofFrontiers in parasitology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary T EfetiFrailty in Ageing Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.ORCID 0009-0000-3837-8322
Sandra N FankemLaboratory of Embryology and Biotechnology, Department of Molecular Biology, Faculty of Science, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Mariama T DialloLaboratory of Embryology and Biotechnology, Department of Molecular Biology, Faculty of Science, Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Methodius S LahngongLaboratory of Pharmacognosy, Center for Interdisciplinary Research on Medicine (CIRM), University of Liege, 4000 Liege, Belgium.ORCID 0009-0003-7851-559X
Nelson L AchaDepartment of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.ORCID 0009-0000-9262-1098
Robert A SheyDepartment of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.ORCID 0000-0003-0146-3894
Kristiaan DemeyerLaboratory of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Department of Analytical, Applied Chemometrics and Molecular Modeling (FABI), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1050 Ixelles, Belgium.
Jacob SouopguiLaboratory of Embryology and Biotechnology, Department of Molecular Biology, Faculty of Science, Université Libre de Bruxelles, 6041 Gosselies, Belgium.ORCID 0000-0003-1526-4431
Stephen M GhogomuDepartment of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.ORCID 0000-0003-3459-6554
Rose NjeminiFrailty in Ageing Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.ORCID 0000-0002-8853-6031

Funding

Académie de recherche et d'enseignement supérieur PRD2020-CamerounVLIR-UOS through Global Minds Joint PhD between Vrije Universiteit Brussel, Belgium, and the University of Buea, Cameroon JointPhD006
6 · The paper itself

Abstract

Malaria is a major public health challenge in low- and middle-income countries with significant socio-economic impacts. While chemotherapy has greatly contributed to malaria control, the widespread emergence of resistance to antimalarial drugs threatens progress towards elimination goals. In parallel, the recent rollout of the RTS,S/AS01 and R21/Matrix-M malaria vaccine-targeting the

Indexed as

Antigens, ProtozoanAntimalarialsDrug ResistanceMalaria, FalciparumMalaria VaccinesPlasmodium falciparumPolymorphism, Single NucleotideProtozoan ProteinsAdolescentAdultCameroonChildChild, PreschoolFemaleHumansMaleAntigens, ProtozoanAntimalarialscircumsporozoite protein, ProtozoanMalaria VaccinesProtozoan Proteinsdrug resistancemalariasingle-nucleotide polymorphismstargeted sequencingvaccine

Identifiers

PMID41226800
PMCPMC12610781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.