Evidence map›Paper›PMID 41226841›Full record

ArticleInternational journal of molecular sciences2025

Therapeutic Modulation of the Nox2-Hv1-ROS Axis by Botulinum Neurotoxin A Confers Protection Against CoCl

Hey Jin Lee, Mira Park, Hyun-Ah Shin, Helen Lew

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hey Jin LeeCHA R&D Institute, CHA University, Seongnam 13496, Gyeonggi-do, Republic of Korea.
Mira ParkDepartment of Ophthalmology, Bundang CHA Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Republic of Korea.
Hyun-Ah ShinDepartment of Biomedical Science, CHA University, Seongnam 13496, Gyeonggi-do, Republic of Korea.
Helen LewDepartment of Ophthalmology, Bundang CHA Medical Center, CHA University, Seongnam 13496, Gyeonggi-do, Republic of Korea.ORCID 0000-0003-0121-3000

Funding

National Research Foundation of Korea (NRF) 2021R1A2C2010523
6 · The paper itself

Abstract

Neuroinflammation and oxidative stress are key drivers of various ocular diseases. Experimental hypoxia, modeled using cobalt chloride (CoCl

Indexed as

Botulinum Toxins, Type ACobaltHypoxiaNADPH Oxidase 2Neuroprotective AgentsReactive Oxygen SpeciesRetinaRetinal DiseasesAnimalsMitochondriaOxidative StressRatsSignal TransductionBotulinum Toxins, Type ACobaltcobaltous chlorideNADPH Oxidase 2Neuroprotective AgentsReactive Oxygen SpeciesBotulinum Toxin AHv1hypoxiaNox2oxidative stressretinal ganglion cells

Identifiers

PMID41226841
PMCPMC12608730

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.