Evidence mapPaperPMID 41226976Full record

ReviewJournal of clinical medicine2025

Gastric Motility Disorders Post Organ Transplantation-A Comprehensive Review.

Hareesha Rishab Bharadwaj, Thai Hau Koo, Dushyant Singh Dahiya, Priyal Dalal, Muhtasim Fuad, Sammy Arab, Karanjot Chhatwal, Taha Bhatti, Maham Malik, Simardeep Singh and 3 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hareesha Rishab BharadwajRoyal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent ST4 6QG, UK.ORCID 0000-0002-7979-2834
Thai Hau KooDivision of Gastroenterology and Hepatology, MetroHealth Medical Centre, Case Western Reserve University, Cleveland, OH 44109, USA.ORCID 0009-0003-6671-0929
Dushyant Singh DahiyaDivision of Gastroenterology, Hepatology and Nutrition, University of Kansas School of Medicine, Kansas City, KS 66160, USA.ORCID 0000-0002-8544-9039
Priyal DalalSchool of Medicine, University of Central Lancashire, Preston PR1 2HE, UK.
Muhtasim FuadRoyal Oldham Hospital, Northern Care Alliance NHS Foundation Trust, Oldham OL1 2JH, UK.
Sammy ArabDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.ORCID 0000-0003-1374-5143
Karanjot ChhatwalImperial College School of Medicine, Imperial College London, London SW7 2AZ, UK.ORCID 0009-0002-8061-6237
Taha BhattiBetsi Cadwaladr University Health Board, Glan Clwyd Hospital, Sarn Ln, Bodelwyddan, Rhyl LL18 5UJ, UK.ORCID 0009-0005-1452-5515
Maham MalikCountess of Chester Hospital NHS Foundation Trust, Liverpool Road, Chester CH2 1UL, UK.ORCID 0000-0002-1589-3417
Simardeep SinghDepartment of Internal Medicine, MedStar Health Georgetown University Baltimore Program, Baltimore, MD 21218, USA.
Fariha HasanDepartment of Internal Medicine, Cooper University Hospital, Camden, NJ 08103, USA.
Christina TofaniDepartment of Gastroenterology, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Anthony InfantolinoDepartment of Gastroenterology, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.ORCID 0009-0001-1024-5517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motility disorders, particularly gastroparesis, are prevalent complications following solid organ transplantation, significantly impacting quality of life, nutritional status, graft survival, and mortality. This comprehensive review synthesises evidence from PubMed, Scopus, and Embase databases on pathophysiology, clinical manifestations, diagnosis, management, and prognostic factors across transplant types. Mechanisms include vagal nerve injury (highest in lung transplants, prevalence 40-91%), immunosuppressive effects (e.g., tacrolimus accelerates motility; mycophenolate impairs it), surgical trauma, microbiome dysbiosis (reduced Firmicutes/Bacteroidetes ratio), and metabolic factors like post-transplant diabetes (OR 5.17 in kidney recipients). Pediatric and thoracic recipients face the highest risks, with lung transplant gastroparesis conferring a 2.7-fold increased mortality/retransplantation hazard (

Indexed as

complicationsgastric motility disordergastrointestinal motilitygastroparesistransplant

Identifiers

PMID41226976
PMCPMC12608437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.