Evidence map›Paper›PMID 41227290›Full record

ReviewCells2025

A Hypothetical Energy-Dissipating Mechanism Regulated by Glucose in β-Cells Preceding Sustained Insulin Secretion.

Jorge Tamarit-Rodriguez

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jorge Tamarit-RodriguezBiochemistry Department, Medical School, Complutense University, 28040 Madrid, Spain.ORCID 0000-0002-6912-8745

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review we propose the hypothesis that an energy-dissipating process precedes the continuous stimulation of insulin secretion by glucose. This process is mediated by connexin 36 hemichannels (Cx36H), or Cx36 connexons. Cx36H oligomers are expressed at the plasma membrane, and their gating activity (opening) is activated by plasma membrane depolarization after the closure of K

Indexed as

Energy MetabolismGlucoseInsulinInsulin-Secreting CellsInsulin SecretionAnimalsConnexinsGap Junction delta-2 ProteinHumansMiceConnexinsGap Junction delta-2 ProteinGlucoseInsulinbeta cell bioenergeticsconnexin36Cx36 hemichannelsglucose oxidative metabolisminsulin secretion

Identifiers

PMID41227290
PMCPMC12608926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.