ReviewCells2025
Mechanical Properties of Endothelial Cells: A Key to Physiology, Drug Testing and Nanostructure Interaction.
Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article explores the application of atomic force spectroscopy in in vitro studies of endothelial cells. In this technique, derived from the atomic force microscopy, the AFM probe is employed as a nanoindenter. This review aims to discuss the nanomechanical properties of endothelial cells alongside selected biological parameters used to determine their physiological state. Changes in cellular elasticity are analyzed in the context of an intracellular mechanism involving nitric oxide, prostacyclin, calcium ions and reactive oxygen species levels. The manuscript compiles various articles on endothelial cells, assessing the impact of different agents such as drugs, cytokines and nanostructures. The review article addresses the endothelial dysfunction model, which is based on alteration in the mechanical properties of the cells, and explains how this model is used for potential drug testing. The next part of the study evaluates the toxic effects of nanostructures on endothelial cells. Additionally, the article addresses the finite element method, a promising new approach for modeling and simulating the behavior of cells treated as a multi-layered structure.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.