Evidence map›Paper›PMID 41227335›Full record

ReviewCells2025

Crosstalk Between Liver and Extra-Liver Organs During Liver Regeneration in Mammals.

Andrey Elchaninov, Daria Bykova, Elena Gantsova, Polina Vishnyakova, Timur Fatkhudinov, Gennady Sukhikh

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The M1/M2 Test System for Determining Macrophage Phenotypes.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrey ElchaninovLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI "Petrovsky National Research Centre of Surgery", 3 Tsurupa Street, 117418 Moscow, Russia.ORCID 0000-0002-2392-4439
Daria BykovaLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI "Petrovsky National Research Centre of Surgery", 3 Tsurupa Street, 117418 Moscow, Russia.ORCID 0000-0001-5639-0835
Elena GantsovaLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI "Petrovsky National Research Centre of Surgery", 3 Tsurupa Street, 117418 Moscow, Russia.ORCID 0000-0003-4925-8005
Polina VishnyakovaResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.ORCID 0000-0001-8650-8240
Timur FatkhudinovLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI "Petrovsky National Research Centre of Surgery", 3 Tsurupa Street, 117418 Moscow, Russia.ORCID 0000-0002-6498-5764
Gennady SukhikhLaboratory of Regenerative Medicine, Institute of Translational Medicine, National Medical Research Centre for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, Russia.

Funding

Russian Science Foundation 25-24-00040
6 · The paper itself

Abstract

Liver diseases are leading causes of death and disability worldwide. Therefore, the development of new treatments for liver disease is urgent. An integral part of the treatment of any liver disease is the process of regeneration of its parenchyma. However, the current approach to studying mammalian liver regeneration is one-sided, focusing solely on the liver itself and neglecting its interactions with other organs. This includes organs of the functional excretory system, such as the lungs and kidneys, which can secrete factors, including HGF, EGF, TGFβ, IL6, and others, into the bloodstream, which influence reparative processes in the liver. Only a few studies exist in this area. However, without a systematic approach to studying liver regeneration, it is impossible to develop new and effective methods to stimulate its regeneration. This review presents data on the interaction of the regenerating liver with the nervous, endocrine, and immune systems, as well as with the lungs, kidneys, and intestines.

Indexed as

LiverLiver RegenerationMammalsAnimalsHumansKidneyLungkidneyliverlungregenerationspleen

Identifiers

PMID41227335
PMCPMC12609221

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.