Evidence mapPaperPMID 41227357Full record

ArticleCells2025

Ladarixin Potential over the Effects of IL-8 and of Serum from Patients with Abdominal Aortic Aneurysm on Human Aortic Cells.

Lucia Spartano, Maria Lombardi, Vincenzo Ardita, Roberto Chiesa, Andrea Aramini, Marcello Allegretti, Domenico Baccellieri, Lidia De Filippis, Chiara Foglieni

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucia SpartanoCardiovascular Research Center, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0009-0002-3577-4826
Maria LombardiCardiovascular Research Center, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-8198-5264
Vincenzo ArditaDivision of Vascular Surgery, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-2923-1470
Roberto ChiesaDivision of Vascular Surgery, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Andrea AraminiDompé Farmaceutici S.p.A., 20122 Milan, Italy.ORCID 0000-0001-8390-6614
Marcello AllegrettiDompé Farmaceutici S.p.A., 20122 Milan, Italy.ORCID 0000-0002-0617-0233
Domenico BaccellieriDivision of Vascular Surgery, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-1201-0508
Lidia De FilippisDompé Farmaceutici S.p.A., 20122 Milan, Italy.ORCID 0000-0002-2196-9430
Chiara FoglieniCardiovascular Research Center, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-5155-6426

Funding

Dompè Farmaceutici S.p.A. NA
6 · The paper itself

Abstract

Early cellular alterations in abdominal aortic aneurysm (AAA) are scarcely investigated. Aortic remodeling inflammation-related suggested the CXCR2/CXCL1/IL-8 axis as a therapeutic target. This study investigates CXCR1/CXCR2 antagonism in primary human aortic endothelial (HAOEC) and smooth muscle cells (HAOSMC) conditioned with IL-8 or serum from patients with AAA (sPT). Ladarixin (10 μM Lad or 25 μM) served as an inhibitor. Readouts included RT-qPCR for

Indexed as

AortaAortic Aneurysm, AbdominalInterleukin-8AgedEndothelial CellsHumansMaleMatrix Metalloproteinase 9MitochondriaMyocytes, Smooth MuscleReceptors, Interleukin-8BVascular Endothelial Growth Factor ACXCL8 protein, humanInterleukin-8Matrix Metalloproteinase 9MMP9 protein, humanReceptors, Interleukin-8BVascular Endothelial Growth Factor ACXCR2/CXCL1/IL-8 axisInterleukin 8 (IL-8)Ladarixin (Lad)Metalloprotease 9 (MMP9)primary human aortic endothelial (HAOEC)primary smooth muscle cells (HAOSMC)

Identifiers

PMID41227357
PMCPMC12610885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.