Evidence map›Paper›PMID 41227370›Full record

ArticleCells2025

Desloratadine Induces

Syed Rashel Kabir, Taufique Abdullah, Gausul Azam, Tamzid Hossain Molla, Hasan Ali, Mojnu Miah, Mohammad Taufiq Alam, Sayem Miah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Syed Rashel KabirDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6025, Bangladesh.ORCID 0000-0002-5708-014X
Taufique AbdullahDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6025, Bangladesh.ORCID 0009-0009-1383-2272
Gausul AzamDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6025, Bangladesh.ORCID 0009-0006-2836-1686
Tamzid Hossain MollaDepartment of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.
Hasan AliDepartment of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6025, Bangladesh.ORCID 0009-0008-8649-1352
Mojnu MiahDepartment of Biochemistry and Molecular Biology, College of Medicine, Winthrop P. Rockefeller Cancer Institute (WPRCI), University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA.
Mohammad Taufiq AlamDepartment of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.
Sayem MiahDepartment of Biochemistry and Molecular Biology, College of Medicine, Winthrop P. Rockefeller Cancer Institute (WPRCI), University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA.ORCID 0000-0002-5901-5181

Funding

Winthrop P. Rockefeller Cancer Institute (WPRCI) NA
6 · The paper itself

Abstract

Breast cancer remains a leading cause of mortality among women despite advances in early detection and targeted therapies, underscoring the need for safer and more effective treatment options. Drug repurposing offers a promising strategy by leveraging existing pharmacological agents with established safety profiles. Desloratadine, a second-generation H1-histamine receptor antagonist widely prescribed for allergic conditions, has attracted interest in oncology because histamine signaling influences proliferation, angiogenesis, and immune responses, yet its anticancer potential remains poorly understood. In this study, we investigated its effects in MCF-7 breast cancer cells, which harbor wild-type

Indexed as

ApoptosisBreast NeoplasmsLoratadineTumor Suppressor Protein p53Cell ProliferationCell SurvivalFemaleHumansMCF-7 CellsMolecular Docking SimulationdesloratadineLoratadineTP53 protein, humanTumor Suppressor Protein p53apoptosisbreast cancerdesloratadinedrug repurposeTP53 gene

Identifiers

PMID41227370
PMCPMC12609754

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.