Advanced Glycation End Products Mediate Epigenetic Alteration of H3K27me3 in Renal Proximal Tubular Cells: Potential Role in Metabolic Memory.

Lore Ludewig, Tzvetanka Bondeva, Marita Liebisch, Jonas Ihle, Ivonne Loeffler, Gunter Wolf

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Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Lore LudewigDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.

Tzvetanka BondevaDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.

Marita LiebischDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.

Jonas IhleDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.

Ivonne LoefflerDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.ORCID 0000-0003-4982-5647

Gunter WolfDepartment of Internal Medicine III, University Hospital Jena, Am Klinikum 1, 07747 Jena, Germany.ORCID 0000-0002-3291-0610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accumulation of advanced glycation end products (AGEs) is a hallmark of prolonged high glucose levels in diabetes mellitus. We have previously reported that hypoxia and AGEs cause epigenetic modification of the repressive mark H3K27me3 in podocytes by downregulation of enhancer of zeste homolog 2 (EZH2) and nuclear inhibitor of protein phosphatase 1 (NIPP1). However, their impact on proximal tubular cells remains unclear. The aim of this study was to investigate the role of AGEs and diabetes on the epigenetic modifications of EZH2 and H3K27me3 in proximal tubular cells and in diabetic (

Indexed as

Epigenesis, GeneticGlycation End Products, AdvancedHistonesKidney Tubules, ProximalAnimalsDiabetic NephropathiesEnhancer of Zeste Homolog 2 ProteinHumansMaleMethylationMiceMice, Inbred C57BLEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseGlycation End Products, AdvancedHistones3-deazaneplanocin Aadvanced glycated end productsAGEsdb/db miceDZNepenhancer of zeste homolog 2EZH2H3K27me3histone 3 K27 tri-methylationmetabolic memory

Identifiers

PMID41227374

DOI10.3390/cells14211729

PMCPMC12607550

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