ReviewAnimals : an open access journal from MDPI2025
Impact of Oxidative Stress and Antioxidants on Semen Quality in Dogs.
Review in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Comparative Evaluation of Staining Techniques in Thawed Cryopreserved Dog Semen.Veterinary sciences · 2026Article
- Protective effects of coenzyme Q10-supplemented cryopreservation medium on oxidative stress in frozen canine sperm.Veterinary research communications · 2026Article
- Nutritional modulation of the gut-reproductive axis: multi-strain probiotic blend on oxidative and seminal parameters in healthy male dogs.Frontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on the biochemical mechanisms of oxidative damage to sperm, the role of antioxidants, as well as the clinical consequences of supplementation for the improvement of sperm fertility. There is growing interest in dog breeding and in methods of maintaining semen quality for natural mating or artificial insemination (AI). Canine sperm are sensitive to oxidative damage. Semen contains endogenous, enzymatic, renewable, and non-enzymatic, and non-renewable antioxidants. However, the excess of reactive oxygen species (ROS) or depletion in antioxidative defense may lead to oxidative stress, causing damage to sperm cells and a decrease in fertility. The possible way to maintain sperm cell fertility potential is supplementation of diet and/or semen extenders with antioxidants. It seems that oral antioxidant supplementation improves the oxidative status and quality of semen and may have a positive effect on the fertility of male dogs with reproductive problems. Many studies point to the potential role of antioxidant supplementation in extenders in protecting canine sperm from oxidative damage during processing. However, only a few studies have assessed the fertilization capacity of supplemented sperm after AI. Intensive studies, including the examination of pro- and antioxidative properties of dog semen as well as the role of antioxidant supplementation to dogs and semen extenders, should be performed, as it is a serious market and breeders need. The results should be related not only to semen analysis but pregnancy rate as the best marker of fertility. Nevertheless, the use of antioxidants in the supportive treatment of fertility disorders in male dogs to improve semen quality and their addition to dog semen extenders to preserve sperm fertility appears to be reasonable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.