Evidence map›Paper›PMID 41227716›Full record

ArticleFoods (Basel, Switzerland)2025

Investigating the Effects of Yunnan Lufeng Aromatic Vinegar Intervention on Intestinal Microbiota, SCFAs, and Metabolites in Mice Using Multi-Omics Techniques.

Hongqin Chen, Ruihuan Zhao, Zhichao Xiao, Yang Li, Junran Yang, Shuaihan Jiang, Sisi Xu, Zhiqiang Xu, Dahai Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Effects of dietaryFrontiers in veterinary science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongqin ChenCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Ruihuan ZhaoCollege of Health, Yunnan Technology and Business University, Kunming 651701, China.
Zhichao XiaoCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.ORCID 0000-0002-8345-1717
Yang LiCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Junran YangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Shuaihan JiangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Sisi XuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Zhiqiang XuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Dahai GuCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.

Funding

The Major Science and Technology Special Project of Yunnan 202502AE090041
6 · The paper itself

Abstract

This study systematically assessed the regulatory effects of Yunnan Lufeng aromatic vinegar (LFAV) on the intestinal microbiota composition, short-chain fatty acids, and cecal metabolites in mice. 16S rRNA high-throughput sequencing revealed that LFAV intervention significantly altered gut microbiota diversity; the M-L group exhibited 19.98% unique operational taxonomic units, while both Chao1 (496.63 ± 42.14) and Shannon indices (6.68 ± 0.32) increased by 37.46% and 3.25%, respectively, compared to the blank group, indicating enhanced microbiota richness. Species composition analysis demonstrated that the relative abundance of Firmicutes reached 75.4% in the M-L group, a 24.4% increase over the B group, whereas Bacteroidetes abundance decreased to 8.2%. GC-MS analysis detected peak butyric acid levels in the M-L group. Untargeted metabolomics identified 520 metabolites, of which 60 were significant differential metabolites. Cluster heatmap and Z-score analyses demonstrated that LFAV intervention significantly modulated mouse metabolites. KEGG pathway enrichment analysis indicated the upregulation of pathways including neuroactive ligand-receptor interactions and renin secretion. Pearson correlation analysis showed a strong positive correlation (

Indexed as

gut microbiotashort-chain fatty acidsuntargeted metabolomicsYunnan Lufeng aromatic vinegar

Identifiers

PMID41227716
PMCPMC12609717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.