Evidence map›Paper›PMID 41228300›Full record

ReviewCancers2025

Pharmacokinetics and Pharmacodynamics of Perfluorooctane Sulfonate (PFOS) and Its Role in the Development and Progression of Prostate, Ovarian and Breast Cancers.

Uche Okuu Arunsi, Daniel Chukwuebuka Ezirim, Chinonye Courage Arunsi, Ahmad Altayyar, Eke Godswill Uche, Favour Chidera Jonathan, Aluba Kalu Opieh, Ifeoma Vivian Anadi, Clinton Ositadinma Ofoegbu, Victor Chukwubuike Nwankwo and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Uche Okuu ArunsiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.ORCID 0000-0002-5315-2695
Daniel Chukwuebuka EzirimDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.ORCID 0009-0000-9045-9736
Chinonye Courage ArunsiDepartment of Nursing Science, Faculty of Health Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Ahmad AltayyarNaz Coker Ovarian Cancer Research Centre (NOVARC), Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-6922-7292
Eke Godswill UcheDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.ORCID 0000-0003-3359-2252
Favour Chidera JonathanDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Aluba Kalu OpiehDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Ifeoma Vivian AnadiDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Clinton Ositadinma OfoegbuDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Victor Chukwubuike NwankwoDepartment of Pharmaceutical Sciences, Irma Lerma Ramgel School of Pharmacy, Texas A&M University, College Station, TX 77843, USA.
Eziuche Amadike UgboguDepartment of Biochemistry, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.ORCID 0000-0003-3145-5473
Paschal Emeka EtusimUnit of Medical Parasitology and Environmental Entomology, Department of Animal and Environmental Biology, Faculty of Biological Sciences, Abia State University, Uturu PMB 2000, Abia State, Nigeria.
Solomon OwumiCancer Research and Molecular Biology Laboratory, Department of Biochemistry, University of Ibadan, Ibadan 200005, Oyo State, Nigeria.ORCID 0000-0002-4973-0376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental pollution, driven by industrialization, urbanization, and agricultural practices, has intensified global ecological degradation. Among the most concerning pollutants is PFOS, a synthetic compound known for its chemical stability, environmental persistence, and bioaccumulative potential. Widely utilised in industrial and consumer products, PFOS infiltrates ecosystems and food chains, posing substantial risks to human and animal health. Upon exposure, PFOS disrupts lipid metabolism, damages cellular membranes, and alters signaling pathways through partial metabolism by cytochrome P450 enzymes. Accumulating evidence links PFOS to oxidative stress, mitochondrial dysfunction, endocrine disruption, neurotoxicity, and immunotoxicity. Critically, PFOS contributes to the development and progression of prostate, breast, and ovarian cancers via mechanisms such as hormonal interference, chronic inflammation, and epigenetic modifications. Epidemiological studies further associate elevated PFOS serum levels with increased cancer risk, particularly in occupationally and environmentally exposed populations. This review brings together the latest knowledge on PFOS emissions, mechanistic toxicity, and cancer-causing potential, highlighting the urgent need for focused research and improved regulatory measures to safeguard public health.

Indexed as

breast cancercarcinogenesisovarian cancerperfluorooctane sulfonatepersistent organic pollutantsprostate cancertoxicodynamicstoxicokinetic

Identifiers

PMID41228300
PMCPMC12609813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.