Evidence map›Paper›PMID 41228316›Full record

ArticleCancers2025

Spheroid-Based 3D Models to Decode Cell Function and Matrix Effectors in Breast Cancer.

Sylvia Mangani, Christos Koutsakis, Nikolaos E Koletsis, Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K Karamanos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sylvia ManganiBiochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.
Christos KoutsakisBiochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.ORCID 0000-0001-8705-7867
Nikolaos E KoletsisBiochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.
Zoi PiperigkouBiochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-0472-5389
Marco FranchiDepartment for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0003-4133-3031
Martin GötteDepartment of Gynecology and Obstetrics, Münster University Hospital, 48149 Münster, Germany.ORCID 0000-0003-2360-2496
Nikos K KaramanosBiochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-3618-0288

Funding

European Union under the Marie Skłodowska-Curie Actions (MSCA), "CARES - Human ECM-based platform for anti-cancer drug testing". x Grant agreement ID: 101130985FEBS as a funding contributor (FEBS Booster Fund).
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

3D breast cancer cell modelsextracellular matrixfunctional cell propertiesmatrix metalloproteinasesspheroidssyndecans

Identifiers

PMID41228316
PMCPMC12606745

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.