Evidence mapPaperPMID 41228332Full record

ReviewCancers2025

Surgical Treatment of Brain Tumor-Related Epilepsy: Current and Emerging Strategies.

Bobak F Khalili, Michael R Chojnacki, Karan Dixit, Kapil Gururangan, Craig Horbinski, Joshua M Rosenow, Jason K Hsieh, Stephen T Magill, Matthew C Tate, Rimas V Lukas and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Inhibitory glutamatergic feedback for brain tumor therapy.Medical oncology (Northwood, London, England) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bobak F KhaliliRush Medical College, Rush University, Chicago, IL 60612, USA.ORCID 0000-0001-5704-5152
Michael R ChojnackiRush Medical College, Rush University, Chicago, IL 60612, USA.
Karan DixitDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-0403-6054
Kapil GururanganDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-5247-8303
Craig HorbinskiDepartment of Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.
Joshua M RosenowDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7726-2496
Jason K HsiehDepartment of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.
Stephen T MagillLou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-5257-7835
Matthew C TateLou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USA.
Rimas V LukasDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9352-5396
Jessica W TemplerDepartment of Neurology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-1850-8868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain tumor-related epilepsy (BTRE) is a common and debilitating symptom of central nervous system (CNS) tumors. The epileptogenic zone, defined as cortex responsible for seizure generation, is located at the peritumoral region for most tumors, and lower-grade intrinsic brain tumors have the highest seizure incidence. Surgery is often the most effective treatment for the reduction in seizures in BTRE. However, surgical decisions have historically often been made exclusively for oncologic reasons, with less emphasis on seizure control. Surgical approaches for all tumor types are reviewed, highlighting relevant risk factors. Adjunctive tools during surgery, such as intraoperative electrocorticography (ECoG), may help identify and remove surrounding brain areas which are epileptogenic. Minimally invasive surgery is also gaining traction, given its utility in treating seizures deep-seated tumors. This review explores epileptogenic brain tumors, surgery for BTRE, and emerging strategies to better achieve seizure control.

Indexed as

brain tumor-related epilepsyelectrocorticographyepilepsygliomaglioneuronal tumorslesional epilepsymeningiomaseizures

Identifiers

PMID41228332
PMCPMC12606746

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.