Evidence map›Paper›PMID 41228401›Full record

Trial reportNutrients2025

Investigating the Digestibility, Bioavailability and Utilization of Protein Blends in Older Adults Using a Dual Stable Isotope Tracer Technique.

Jake Cox, Bethan E Phillips, James Bunce, Thomas Smart, Joshua Wall, Hannah Crossland, Daniel J Wilkinson, Kenneth Smith, Philip J Atherton

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jake CoxCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.ORCID 0000-0001-6141-5216
Bethan E PhillipsCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.
James BunceCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.
Thomas SmartCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.ORCID 0000-0003-4518-1004
Joshua WallCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.ORCID 0000-0002-9874-1936
Hannah CrosslandCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.ORCID 0000-0002-9009-3049
Daniel J WilkinsonCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.
Kenneth SmithCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.
Philip J AthertonCOMAP Research Group, School of Medicine, Faculty of Medicine and Health Science, University of Nottingham, Nottingham DE22 3DT, UK.ORCID 0000-0002-7286-046X

Funding

Fresenius Kabi FK
6 · The paper itself

Abstract

objectivesThe impact of combining animal and plant protein sources on digestibility is unclear, despite their increasing clinical use. Using a non-invasive dual stable isotope tracer approach, we assessed the digestibility, bioavailability and utilization of distinct protein blends in older adults, and associated plasma amino acid profiles and muscle protein synthesis (MPS) rates.

methodsThirty-two older men (69 ± 3 y) consumed one of four protein blends (A (51:49, casein/soy); B and C (35:25:20:20, whey/casein/soy/pea); D (80:20, casein/whey)) alongside primed constant infusions of [1,2-

resultsNo differences (

conclusionsThese findings suggest that protein quantity (and/or leucine content), rather than composition, appears to be the most important factor driving MPS. Future work should focus on clinical populations where protein requirements and digestibility characteristics may differ.

Indexed as

Dietary ProteinsDigestionAgedAmino AcidsBiological AvailabilityCarbon IsotopesCaseinsHumansIsotope LabelingLeucineMaleMuscle ProteinsSoybean ProteinsWhey ProteinsAmino AcidsCarbon IsotopesCaseinsDietary ProteinsLeucineMuscle ProteinsSoybean ProteinsWhey Proteinsageingdual stable isotopeprotein digestibilityprotein synthesisskeletal muscle

Identifiers

PMID41228401
PMCPMC12609865

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.